50638-49-8

Basic information

• Product Name: 4-Bromo-2,N,N-trimethylaniline
• Synonyms: 4-Bromo-2,N,N-trimethylaniline;1-Bromo-4-(dimethylamino)-3-methylbenzene;BenzenaMine, 4-broMo-N,N,2-triMethyl-;(4-Bromo-2-methyl-phenyl)-dimethyl-amine
• CAS NO: 50638-49-8
• Molecular Formula: C₉H₁₂BrN
• Molecular Weight: 214.10228
• Product Categories: Amino;Aryl;Organohalides
• Mol File: 50638-49-8.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-Bromo-2,N,N-trimethylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-2,N,N-trimethylaniline(50638-49-8)
• EPA Substance Registry System: 4-Bromo-2,N,N-trimethylaniline(50638-49-8)

Safety Data

• Hazardous Substances Data: 50638-49-8(Hazardous Substances Data)

Usage

General Description

4-Bromo-2,N,N-trimethylaniline is a chemical compound with the molecular formula C9H12BrN. It is part of the aniline and substituted aniline family of organic compounds, which are characterized by their use in the production of dyes, drugs, and plastics. This specific compound features an aniline group (a phenyl group attached to an amino group) that has been substituted with three methyl groups and a bromine atom. The presence of the bromine atom often suggests that this compound may play a role in coupling reactions - a type of chemical reaction where two hydrocarbon fragments are joined together. Like other anilines, it needs to be handled with care as it may be harmful or toxic.

Upstream product

• 64-19-7 acetic acid 
• 67-56-1 methanol 
• 583-75-5 4-Bromo-2-methylaniline 
• 512-56-1 trimethyl phosphite 
• 609-72-3 N,N-dimethyl-o-toluidine 
• 7726-95-6 bromine 
• 50-00-0 formaldehyd 
• 6852-47-7 N,N-dimethyl-N-(2'-methylphenyl)amine N-oxide 
• 74-88-4 methyl iodide 
• 64230-27-9 2,4-dibromo-N,N-dimethylaniline 
• 7732-18-5 water 
• 7647-01-0 hydrogenchloride 
• 30273-41-7 2,4-dibromo-6-methylaniline 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 1613259-64-5 N,N,2-trimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 
• 27751-12-8 2,N,N,N',N'-pentamethyl-p-phenylenediamine 
• 99768-14-6 N-(4-bromo-2-methylphenyl)-N-methylnitrous amide 
• 1070716-56-1 2-[4-(dimethylamino)-3-methylphenyl]hexanal 
• 1070716-58-3 4-(benzyloxy)-2-[4-(dimethylamino)-3-methylphenyl]butanal 
• 106269-97-0 4-dimethylamino-3-methyl-benzoic acid ethyl ester 
• 96818-62-1 bis(n-butylsulfenyl)(N,N-dimethylamino)methylbenzene 
• 96818-61-0 (4,5-Dibromo-2-methyl-phenyl)-dimethyl-amine 
• 3564-94-1 N⁴,N⁴,N^4',N^4',3,3'-hexamethyl-[1,1'-biphenyl]-4,4'-diamine 
• 103030-89-3 4-(N,N-dimethylamino)-3-methylbenzoic acid 

Relevant articles and documents

Novel monoacylglycerol lipase inhibitor as well as preparation method and application thereof

The invention discloses a novel monoacylglycerol lipase inhibitor as well as a preparation method and application thereof. Specifically, the invention provides a compound shown as a formula I, or a pharmaceutically acceptable salt, a stereoisomer, or a deuterated derivative thereof. Experimental results show that the compound provided by the invention can effectively inhibit MAGL activity, can beused for preparing an MAGL inhibitor and preparing medicines for preventing and/or treating diseases (including endometrial cancer, colorectal cancer, liver cancer, breast cancer, ovarian cancer, neurodegenerative diseases and the like) related to abnormal MAGL activity, and has a wide application prospect.

Synthesis of Halogenated Anilines by Treatment of N, N-Dialkylaniline N-Oxides with Thionyl Halides

The special reactivity of N,N-dialkylaniline N-oxides allows practical and convenient access to electron-rich aryl halides. A complementary pair of reaction protocols allow for the selective para-bromination or ortho-chlorination of N,N-dialkylanilines in up to 69% isolated yield. The generation of a diverse array of halogenated anilines is made possible by a temporary oxidation level increase of N,N-dialkylanilines to the corresponding N,N-dialkylaniline N-oxides and the excision of the resultant weak N-O bond via treatment with thionyl bromide or thionyl chloride at low temperature.

SUBSTITUTED PYRIDOPYRAZINES AS SYK INHIBITORS

The present invention relates to pyridopyrazine compounds of formula (I), pharmaceutical compositions thereof and methods of use therefore, wherein R1, R2, R3, L, m, p and W are as defined in the specification.