50638-49-8

Usage

Uses

Used in Pharmaceutical Industry:
4-Bromo-2,N,N-trimethylaniline is used as an intermediate compound for the synthesis of various drugs. Its unique structure allows it to be a key component in the development of new pharmaceuticals, contributing to the creation of novel therapeutic agents.
Used in Dye Production:
4-Bromo-2,N,N-trimethylaniline is used as a precursor in the production of dyes. Its chemical properties make it suitable for the synthesis of a range of dyes, which can be used in various industries such as textiles, plastics, and printing.
Used in Plastics Industry:
4-Bromo-2,N,N-trimethylaniline is used as a monomer in the production of certain types of plastics. Its chemical structure can be polymerized to form plastics with specific properties, such as improved strength or resistance to certain conditions, making it a valuable component in the development of new materials.
Used in Chemical Research:
4-Bromo-2,N,N-trimethylaniline is used as a research compound in various chemical studies. Its unique structure and reactivity make it an interesting subject for investigation, potentially leading to new discoveries and applications in the field of chemistry.

Upstream product

• 67-66-3 chloroform 
• 64-19-7 acetic acid 
• 67-64-1 acetone 
• 67-56-1 methanol 
• 583-75-5 4-Bromo-2-methylaniline 
• 512-56-1 trimethyl phosphite 
• 609-72-3 N,N-dimethyl-o-toluidine 
• 7726-95-6 bromine 
• 7732-18-5 water 
• 64230-27-9 2,4-dibromo-N,N-dimethylaniline 
• 74-88-4 methyl iodide 
• 50-00-0 formaldehyd 
• 6852-47-7 N,N-dimethyl-N-(2'-methylphenyl)amine N-oxide 
• 7647-01-0 hydrogenchloride 

Downstream Products

• 96818-61-0 (4,5-Dibromo-2-methyl-phenyl)-dimethyl-amine 
• 3564-94-1 N⁴,N⁴,N^4',N^4',3,3'-hexamethyl-[1,1'-biphenyl]-4,4'-diamine 
• 1613259-64-5 N,N,2-trimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 
• 27751-12-8 2,N,N,N',N'-pentamethyl-p-phenylenediamine 
• 103030-89-3 4-(N,N-dimethylamino)-3-methylbenzoic acid 
• 99768-14-6 N-(4-bromo-2-methylphenyl)-N-methylnitrous amide 
• 1070716-56-1 2-[4-(dimethylamino)-3-methylphenyl]hexanal 
• 1070716-58-3 4-(benzyloxy)-2-[4-(dimethylamino)-3-methylphenyl]butanal 
• 106269-97-0 4-dimethylamino-3-methyl-benzoic acid ethyl ester 
• 96818-62-1 bis(n-butylsulfenyl)(N,N-dimethylamino)methylbenzene 

Relevant academic research and scientific papers

Novel monoacylglycerol lipase inhibitor as well as preparation method and application thereof

The invention discloses a novel monoacylglycerol lipase inhibitor as well as a preparation method and application thereof. Specifically, the invention provides a compound shown as a formula I, or a pharmaceutically acceptable salt, a stereoisomer, or a deuterated derivative thereof. Experimental results show that the compound provided by the invention can effectively inhibit MAGL activity, can beused for preparing an MAGL inhibitor and preparing medicines for preventing and/or treating diseases (including endometrial cancer, colorectal cancer, liver cancer, breast cancer, ovarian cancer, neurodegenerative diseases and the like) related to abnormal MAGL activity, and has a wide application prospect.

DOCK1-INHIBITING COMPOUND AND USE THEREOF

Provided is a compound that is usable as an active ingredient of an anticancer agent. Preferably provided is a compound that has DOCK1-inhibiting activity and exerts an anticancer effect based on the activity. A compound represented by the following formula (A) or a salt thereof: wherein X represents a carbon atom or a nitrogen atom; Y represents an oxygen atom, a hydroxy group, or a hydrocarbon group; R1 and R2 are different, and each represents a hydrogen atom or a group represented by the following formula (A-1): (wherein R6 represents a pyrrolidino group or a phenyl group, and n2 is 0 or 1) ; R3 represents -CO-R7 (wherein R7 is an alkoxy group, an alkyl group, or an alkylamino group), a 1,3-oxazole group, an alkylhydroxy group, a hydrogen atom, or an oxygen atom; R4 represents a hydrogen atom, an oxygen atom, or a hydrocarbon group in which one or more hydrogen atoms may be replaced by one or more substituents; R5 represents a halogen atom, a halogenated alkyl group, or a halogenated alkylthio group; and n1 is an integer of 0 to 5; and

Synthesis of Halogenated Anilines by Treatment of N, N-Dialkylaniline N-Oxides with Thionyl Halides

The special reactivity of N,N-dialkylaniline N-oxides allows practical and convenient access to electron-rich aryl halides. A complementary pair of reaction protocols allow for the selective para-bromination or ortho-chlorination of N,N-dialkylanilines in up to 69% isolated yield. The generation of a diverse array of halogenated anilines is made possible by a temporary oxidation level increase of N,N-dialkylanilines to the corresponding N,N-dialkylaniline N-oxides and the excision of the resultant weak N-O bond via treatment with thionyl bromide or thionyl chloride at low temperature.

Nickel-catalyzed C-N bond reduction of aromatic and benzylic quaternary ammonium triflates

A nickel-catalyzed, efficient C-N bond reduction of aromatic and benzylic ammonium triflates has been developed using sodium isopropoxide as a reducing agent. The high efficiency, mild conditions, and good compatibility with various substituents made this method an effective supplement to the current catalytic hydrogenation reactions. Combining this reductive deamination reaction with directed aromatic functionalization reactions, a powerful strategy for regioselective functionalization of arenes was demonstrated using dialkylamine groups as traceless directing groups.

SUBSTITUTED PYRIDOPYRAZINES AS SYK INHIBITORS

The present invention relates to pyridopyrazine compounds of formula (I), pharmaceutical compositions thereof and methods of use therefore, wherein R1, R2, R3, L, m, p and W are as defined in the specification.

Use of methyllithium in metal/halogen exchange; a mild and efficient method for the synthesis of ortho substituted toluenes

Methyllithium, in the presence of excess methyl iodide, can be used to convert suitably substituted aromatic bromides to the corresponding toluenes under mild conditions and in high yield.