N-(1(S)-carbomethoxy-3-methylthiopropyl)3-azidomethylbenzamide

Base Information

• Chemical Name: N-(1(S)-carbomethoxy-3-methylthiopropyl)3-azidomethylbenzamide
• CAS No.: 180863-47-2
• Molecular Formula: C₁₄H₁₈N₄O₃S
• Molecular Weight: 322.388
• Mol file: 180863-47-2.mol

Synonyms:N-(1(S)-carbomethoxy-3-methylthiopropyl)3-azidomethylbenzamide

Chemical Property of N-(1(S)-carbomethoxy-3-methylthiopropyl)3-azidomethylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(1(S)-carbomethoxy-3-methylthiopropyl)3-azidomethylbenzamide

There total 1 articles about N-(1(S)-carbomethoxy-3-methylthiopropyl)3-azidomethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(1(S)-carbomethoxy-3-methylthiopropyl)3-chloromethylbenzamide (180863-46-1) → N-(1(S)-carbomethoxy-3-methylthiopropyl)3-azidomethylbenzamide (180863-47-2)

Guidance literature:

With lithium azide; In dimethyl sulfoxide;

DOI:10.1016/S0960-894X(99)00323-6

Reference yield:

N-(1(S)-carbomethoxy-3-methylthiopropyl)3-azidomethylbenzamide (180863-47-2) → N-(1(S)-carbomethoxy-3-methylthiopropyl)3-aminomethylbenzamide (160813-66-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1016/S0960-894X(99)00323-6

Reference yield:

N-(1(S)-carbomethoxy-3-methylthiopropyl)3-azidomethylbenzamide (180863-47-2) → 2-(3-{[benzyl-(1H-imidazol-4-ylmethyl)-amino]-methyl}-benzoylamino)-4-methylsulfanyl-butyric acid methyl ester

Guidance literature:

Multi-step reaction with 4 steps

1: H₂ / 10 percent Pd/C / methanol

2: Na(OAc)3BH, 4 A MS / 1,2-dichloro-ethane / 0 - 20 °C

3: Na(OAc)3BH, 4 A MS / 1,2-dichloro-ethane / 0 - 20 °C

4: TFA, Et₃SiH / CH₂Cl₂ / 0 - 20 °C

With triethylsilane; hydrogen; sodium tris(acetoxy)borohydride; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; 1,2-dichloro-ethane;

DOI:10.1016/S0960-894X(99)00323-6

upstream raw materials:

N-(1(S)-carbomethoxy-3-methylthiopropyl)3-chloromethylbenzamide

Downstream raw materials:

N-(1(S)-carbomethoxy-3-methylthiopropyl)3-aminomethylbenzamide

2-(3-{[(1H-imidazol-4-ylmethyl)-amino]-methyl}-benzoylamino)-4-methylsulfanyl-butyric acid methyl ester

N-(1(S)-carbomethoxy-3-methylthiopropyl)3-[(4-imidazolylmethyl)-N-methylaminomethyl]benzamide

2-(3-{[bis-(1H-imidazol-4-ylmethyl)-amino]-methyl}-benzoylamino)-4-methylsulfanyl-butyric acid methyl ester