N-(1(S)-carbomethoxy-3-methylthiopropyl)3-aminomethylbenzamide

Base Information

• Chemical Name: N-(1(S)-carbomethoxy-3-methylthiopropyl)3-aminomethylbenzamide
• CAS No.: 160813-66-1
• Molecular Formula: C₁₄H₂₀N₂O₃S
• Molecular Weight: 296.39
• Mol file: 160813-66-1.mol

Synonyms:N-(1(S)-carbomethoxy-3-methylthiopropyl)3-aminomethylbenzamide

Chemical Property of N-(1(S)-carbomethoxy-3-methylthiopropyl)3-aminomethylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(1(S)-carbomethoxy-3-methylthiopropyl)3-aminomethylbenzamide

There total 2 articles about N-(1(S)-carbomethoxy-3-methylthiopropyl)3-aminomethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(1(S)-carbomethoxy-3-methylthiopropyl)3-azidomethylbenzamide (180863-47-2) → N-(1(S)-carbomethoxy-3-methylthiopropyl)3-aminomethylbenzamide (160813-66-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1016/S0960-894X(99)00323-6

Reference yield:

N-(1(S)-carbomethoxy-3-methylthiopropyl)3-chloromethylbenzamide (180863-46-1) → N-(1(S)-carbomethoxy-3-methylthiopropyl)3-aminomethylbenzamide (160813-66-1)

Guidance literature:

Multi-step reaction with 2 steps

1: LiN₃ / dimethylsulfoxide

2: H₂ / 10 percent Pd/C / methanol

With lithium azide; hydrogen; palladium on activated charcoal; In methanol; dimethyl sulfoxide;

DOI:10.1016/S0960-894X(99)00323-6

Reference yield:

? molecular sieves + (1-tritylimidazol-4-yl)carboxaldehyde (33016-47-6) + N-(1(S)-carbomethoxy-3-methylthiopropyl)3-aminomethylbenzamide (160813-66-1) → N-(1(S)-carbomethoxy-3-methylthiopropyl)3-[(1-triphenylmethyl)-4-imidazolylmethyl]aminomethyl benzamide

Guidance literature:

With sodium tris(acetoxy)borohydride; In water; acetic acid; ethyl acetate; 1,2-dichloro-ethane;

upstream raw materials:

N-(1(S)-carbomethoxy-3-methylthiopropyl)3-azidomethylbenzamide

N-(1(S)-carbomethoxy-3-methylthiopropyl)3-chloromethylbenzamide

Downstream raw materials:

4-methylsulfanyl-2-(3-{[(1-trityl-1H-imidazol-4-ylmethyl)-amino]-methyl}-benzoylamino)-butyric acid methyl ester

2-(3-{[bis-(1-trityl-1H-imidazol-4-ylmethyl)-amino]-methyl}-benzoylamino)-4-methylsulfanyl-butyric acid methyl ester

2-(3-{[(1H-imidazol-4-ylmethyl)-amino]-methyl}-benzoylamino)-4-methylsulfanyl-butyric acid methyl ester

N-(1(S)-carbomethoxy-3-methylthiopropyl)3-[(4-imidazolylmethyl)-N-methylaminomethyl]benzamide