N-(1(S)-carbomethoxy-3-methylthiopropyl)3-chloromethylbenzamide

Base Information

• Chemical Name: N-(1(S)-carbomethoxy-3-methylthiopropyl)3-chloromethylbenzamide
• CAS No.: 180863-46-1
• Molecular Formula: C₁₄H₁₈ClNO₃S
• Molecular Weight: 315.821
• Mol file: 180863-46-1.mol

Synonyms:N-(1(S)-carbomethoxy-3-methylthiopropyl)3-chloromethylbenzamide

Chemical Property of N-(1(S)-carbomethoxy-3-methylthiopropyl)3-chloromethylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(1(S)-carbomethoxy-3-methylthiopropyl)3-chloromethylbenzamide

There total 1 articles about N-(1(S)-carbomethoxy-3-methylthiopropyl)3-chloromethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methyl-morpholine (109-02-4) + 3-(Chloromethyl)benzoyl chloride (63024-77-1) + methionine methyl ester hydrochloride (16118-36-8) → N-(1(S)-carbomethoxy-3-methylthiopropyl)3-chloromethylbenzamide (180863-46-1)

Guidance literature:

With potassium hydrogen sulphate; In dichloromethane;

Reference yield:

N-(1(S)-carbomethoxy-3-methylthiopropyl)3-chloromethylbenzamide (180863-46-1) → N-(1(S)-carbomethoxy-3-methylthiopropyl)3-azidomethylbenzamide (180863-47-2)

Guidance literature:

With lithium azide; In dimethyl sulfoxide;

DOI:10.1016/S0960-894X(99)00323-6

Reference yield:

N-(1(S)-carbomethoxy-3-methylthiopropyl)3-chloromethylbenzamide (180863-46-1) → N-(1(S)-carbomethoxy-3-methylthiopropyl)3-aminomethylbenzamide (160813-66-1)

Guidance literature:

Multi-step reaction with 2 steps

1: LiN₃ / dimethylsulfoxide

2: H₂ / 10 percent Pd/C / methanol

With lithium azide; hydrogen; palladium on activated charcoal; In methanol; dimethyl sulfoxide;

DOI:10.1016/S0960-894X(99)00323-6

upstream raw materials:

4-methyl-morpholine

3-(Chloromethyl)benzoyl chloride

methionine methyl ester hydrochloride

Downstream raw materials:

N-(1(S)-carbomethoxy-3-methylthiopropyl)3-azidomethylbenzamide

N-(1(S)-carbomethoxy-3-methylthiopropyl)3-aminomethylbenzamide

2-(3-{[(1H-imidazol-4-ylmethyl)-amino]-methyl}-benzoylamino)-4-methylsulfanyl-butyric acid methyl ester

N-(1(S)-carbomethoxy-3-methylthiopropyl)3-[(4-imidazolylmethyl)-N-methylaminomethyl]benzamide