2-(4-fluorophenyl)-5-(4-hydroxyphenyl)-N-methyl-6-[methyl(methylsulfonyl)amino]-1-benzofuran-3-carboxamide

Base Information

Chemical Name:2-(4-fluorophenyl)-5-(4-hydroxyphenyl)-N-methyl-6-[methyl(methylsulfonyl)amino]-1-benzofuran-3-carboxamide
CAS No.:1333224-46-6
Molecular Formula:C₂₄H₂₁FN₂O₅S
Molecular Weight:468.506
Hs Code.:

Synonyms:2-(4-fluorophenyl)-5-(4-hydroxyphenyl)-N-methyl-6-[methyl(methylsulfonyl)amino]-1-benzofuran-3-carboxamide

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Chemical Property of 2-(4-fluorophenyl)-5-(4-hydroxyphenyl)-N-methyl-6-[methyl(methylsulfonyl)amino]-1-benzofuran-3-carboxamide

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Technology Process of 2-(4-fluorophenyl)-5-(4-hydroxyphenyl)-N-methyl-6-[methyl(methylsulfonyl)amino]-1-benzofuran-3-carboxamide

There total 13 articles about 2-(4-fluorophenyl)-5-(4-hydroxyphenyl)-N-methyl-6-[methyl(methylsulfonyl)amino]-1-benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.5%

: 1333225-20-9
5-bromo-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzo furan-3-carboxamide

: 71597-85-8
(p-hydroxyphenyl)boronic acid

: 1333224-46-6
2-(4-fluorophenyl)-5-(4-hydroxyphenyl)-N-methyl-6-[methyl(methylsulfonyl)amino]-1-benzofuran-3-carboxamide

Guidance literature:: With potassium phosphate tribasic trihydrate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 90 ℃; for 12h; Inert atmosphere;

Reference yield:

: 614-75-5
2-Hydroxyphenylacetic acid

: 1333224-46-6
2-(4-fluorophenyl)-5-(4-hydroxyphenyl)-N-methyl-6-[methyl(methylsulfonyl)amino]-1-benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 12 steps

1.1: tetra-N-butylammonium tribromide / 18 h / 20 °C

2.1: 1H-imidazole / dichloromethane / 0 - 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

3.2: 2 h / -78 - 0 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C

5.1: hydrogenchloride / water; acetone / 0.5 h / Radiolysis

6.1: nitric acid / chloroform / 4 h / 20 °C

7.1: water; iron; ammonium chloride / tetrahydrofuran; methanol / 3 h / Reflux

8.1: pyridine / dichloromethane / 0 - 20 °C

9.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / Inert atmosphere; Reflux

10.1: lithium hydroxide monohydrate / 1,4-dioxane; water / 2 h / 100 °C

10.2: pH 3

11.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 20 °C

12.1: potassium phosphate tribasic trihydrate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 12 h / 90 °C / Inert atmosphere

With pyridine; 1H-imidazole; hydrogenchloride; lithium hydroxide monohydrate; potassium phosphate tribasic trihydrate; tetrabutyl ammonium fluoride; water; nitric acid; tetra-N-butylammonium tribromide; iron; potassium carbonate; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide; lithium hexamethyldisilazane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 220801-66-1
5-bromo-2-hydroxylphenylacetic acid methyl ester

: 1333224-46-6
2-(4-fluorophenyl)-5-(4-hydroxyphenyl)-N-methyl-6-[methyl(methylsulfonyl)amino]-1-benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: 1H-imidazole / dichloromethane / 0 - 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

2.2: 2 h / -78 - 0 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C

4.1: hydrogenchloride / water; acetone / 0.5 h / Radiolysis

5.1: nitric acid / chloroform / 4 h / 20 °C

6.1: water; iron; ammonium chloride / tetrahydrofuran; methanol / 3 h / Reflux

7.1: pyridine / dichloromethane / 0 - 20 °C

8.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / Inert atmosphere; Reflux

9.1: lithium hydroxide monohydrate / 1,4-dioxane; water / 2 h / 100 °C

9.2: pH 3

10.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 20 °C

11.1: potassium phosphate tribasic trihydrate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 12 h / 90 °C / Inert atmosphere

With pyridine; 1H-imidazole; hydrogenchloride; lithium hydroxide monohydrate; potassium phosphate tribasic trihydrate; tetrabutyl ammonium fluoride; water; nitric acid; iron; potassium carbonate; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide; lithium hexamethyldisilazane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetone;