ethyl 7-(7-(piperidin-1-yl)-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoate

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Chemical Name:ethyl 7-(7-(piperidin-1-yl)-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoate
CAS No.:1447306-92-4
Molecular Formula:C₃₅H₄₆N₄O₂
Molecular Weight:554.776
Hs Code.:

Synonyms:ethyl 7-(7-(piperidin-1-yl)-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoate

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Chemical Property of ethyl 7-(7-(piperidin-1-yl)-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoate

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Technology Process of ethyl 7-(7-(piperidin-1-yl)-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoate

There total 8 articles about ethyl 7-(7-(piperidin-1-yl)-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3990-05-4
ethyl 6-formylhexanoate

: 1447306-91-3
7-(piperidin-1-yl)-2,3-di-p-tolyl-5,6,7,8-tetrahydropyrido[2,3-b]pyrazine

: 1447306-92-4
ethyl 7-(7-(piperidin-1-yl)-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoate

Guidance literature:: With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; Inert atmosphere;

Reference yield:

: 2,3-di-p-tolylpyrido[2,3-b]pyrazine

: 1447306-92-4
ethyl 7-(7-(piperidin-1-yl)-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.13 h / 5 °C / Inert atmosphere

1.2: 20 - 40 °C

2.1: methyl tributylammonium chloride; potassium permanganate / dichloromethane / 0.83 h / 0 - 20 °C / Inert atmosphere

3.1: tetrahydrofuran / 3 h / Reflux

4.1: tri-n-butyl-tin hydride / toluene / 20 °C / Reflux

5.1: pyridine / 20 °C

6.1: 20 °C / Sonication

7.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

8.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere

With pyridine; potassium permanganate; lithium aluminium tetrahydride; tri-n-butyl-tin hydride; sodium tris(acetoxy)borohydride; methyl tributylammonium chloride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; toluene;

Reference yield:

: 1356332-98-3
7,8-dihydroxy-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-carboxylic acid tert-butyl ester

: 1447306-92-4
ethyl 7-(7-(piperidin-1-yl)-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoate

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / 3 h / Reflux

2: tri-n-butyl-tin hydride / toluene / 20 °C / Reflux

3: pyridine / 20 °C

4: 20 °C / Sonication

5: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

6: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere

With pyridine; tri-n-butyl-tin hydride; sodium tris(acetoxy)borohydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; toluene;