rac-tert-butyl 2-thioxo-7,8-di-p-tolyl-3a,4-dihydro-[1,3]dioxolo[4',5':4,5]pyrido[2,3-b]pyrazine-5(9bH)-carboxylate

Base Information

Chemical Name:rac-tert-butyl 2-thioxo-7,8-di-p-tolyl-3a,4-dihydro-[1,3]dioxolo[4',5':4,5]pyrido[2,3-b]pyrazine-5(9bH)-carboxylate
CAS No.:1447306-88-8
Molecular Formula:C₂₇H₂₇N₃O₄S
Molecular Weight:489.595
Hs Code.:

Synonyms:rac-tert-butyl 2-thioxo-7,8-di-p-tolyl-3a,4-dihydro-[1,3]dioxolo[4',5':4,5]pyrido[2,3-b]pyrazine-5(9bH)-carboxylate

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Chemical Property of rac-tert-butyl 2-thioxo-7,8-di-p-tolyl-3a,4-dihydro-[1,3]dioxolo[4',5':4,5]pyrido[2,3-b]pyrazine-5(9bH)-carboxylate

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Technology Process of rac-tert-butyl 2-thioxo-7,8-di-p-tolyl-3a,4-dihydro-[1,3]dioxolo[4',5':4,5]pyrido[2,3-b]pyrazine-5(9bH)-carboxylate

There total 8 articles about rac-tert-butyl 2-thioxo-7,8-di-p-tolyl-3a,4-dihydro-[1,3]dioxolo[4',5':4,5]pyrido[2,3-b]pyrazine-5(9bH)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356332-98-3
7,8-dihydroxy-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-carboxylic acid tert-butyl ester

: 6160-65-2
1,1'-Thiocarbonyldiimidazole

: 1447306-88-8
rac-tert-butyl 2-thioxo-7,8-di-p-tolyl-3a,4-dihydro-[1,3]dioxolo[4',5':4,5]pyrido[2,3-b]pyrazine-5(9bH)-carboxylate

Guidance literature:: In tetrahydrofuran; for 3h; Reflux;

Reference yield:

: 1356332-97-2
2,3-di-p-tolylpyrido[2,3-b]pyrazine-5(6H)-carboxylic acid tert-butyl ester

: 1447306-88-8
rac-tert-butyl 2-thioxo-7,8-di-p-tolyl-3a,4-dihydro-[1,3]dioxolo[4',5':4,5]pyrido[2,3-b]pyrazine-5(9bH)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: methyl tributylammonium chloride; potassium permanganate / dichloromethane / 0.83 h / 0 - 20 °C / Inert atmosphere

2: tetrahydrofuran / 3 h / Reflux

With potassium permanganate; methyl tributylammonium chloride; In tetrahydrofuran; dichloromethane;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1447306-88-8
rac-tert-butyl 2-thioxo-7,8-di-p-tolyl-3a,4-dihydro-[1,3]dioxolo[4',5':4,5]pyrido[2,3-b]pyrazine-5(9bH)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.13 h / 5 °C / Inert atmosphere

1.2: 20 - 40 °C

2.1: methyl tributylammonium chloride; potassium permanganate / dichloromethane / 0.83 h / 0 - 20 °C / Inert atmosphere

3.1: tetrahydrofuran / 3 h / Reflux

With potassium permanganate; lithium aluminium tetrahydride; methyl tributylammonium chloride; In tetrahydrofuran; dichloromethane;