7-(7-(piperidin-1-yl)-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

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Chemical Name:7-(7-(piperidin-1-yl)-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid
CAS No.:1447305-23-8
Molecular Formula:C₃₃H₄₂N₄O₂
Molecular Weight:526.722
Hs Code.:

Synonyms:7-(7-(piperidin-1-yl)-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

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Chemical Property of 7-(7-(piperidin-1-yl)-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

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Technology Process of 7-(7-(piperidin-1-yl)-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

There total 9 articles about 7-(7-(piperidin-1-yl)-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1447306-92-4
ethyl 7-(7-(piperidin-1-yl)-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoate

: 1447305-23-8
7-(7-(piperidin-1-yl)-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

Guidance literature:: With ethanol; sodium hydroxide; at 20 ℃;

Reference yield:

: 1356332-97-2
2,3-di-p-tolylpyrido[2,3-b]pyrazine-5(6H)-carboxylic acid tert-butyl ester

: 1447305-23-8
7-(7-(piperidin-1-yl)-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: methyl tributylammonium chloride; potassium permanganate / dichloromethane / 0.83 h / 0 - 20 °C / Inert atmosphere

2: tetrahydrofuran / 3 h / Reflux

3: tri-n-butyl-tin hydride / toluene / 20 °C / Reflux

4: pyridine / 20 °C

5: 20 °C / Sonication

6: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

7: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere

8: sodium hydroxide; ethanol / 20 °C

With pyridine; potassium permanganate; ethanol; tri-n-butyl-tin hydride; sodium tris(acetoxy)borohydride; methyl tributylammonium chloride; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; toluene;

Reference yield:

: 2,3-di-p-tolylpyrido[2,3-b]pyrazine

: 1447305-23-8
7-(7-(piperidin-1-yl)-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.13 h / 5 °C / Inert atmosphere

1.2: 20 - 40 °C

2.1: methyl tributylammonium chloride; potassium permanganate / dichloromethane / 0.83 h / 0 - 20 °C / Inert atmosphere

3.1: tetrahydrofuran / 3 h / Reflux

4.1: tri-n-butyl-tin hydride / toluene / 20 °C / Reflux

5.1: pyridine / 20 °C

6.1: 20 °C / Sonication

7.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

8.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere

9.1: sodium hydroxide; ethanol / 20 °C

With pyridine; potassium permanganate; lithium aluminium tetrahydride; ethanol; tri-n-butyl-tin hydride; sodium tris(acetoxy)borohydride; methyl tributylammonium chloride; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; toluene;