2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-(5-(5-(1-isopropylpiperidin-4-yl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)benzyl acetate

Base Information

Chemical Name:2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-(5-(5-(1-isopropylpiperidin-4-yl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)benzyl acetate
CAS No.:1360056-63-8
Molecular Formula:C₃₉H₄₄FN₇O₄
Molecular Weight:693.821
Hs Code.:

2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-(5-(5-(1-isopropylpiperidin-4-yl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)benzyl acetate

Synonyms:2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-(5-(5-(1-isopropylpiperidin-4-yl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)benzyl acetate

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Chemical Property of 2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-(5-(5-(1-isopropylpiperidin-4-yl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)benzyl acetate

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Technology Process of 2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-(5-(5-(1-isopropylpiperidin-4-yl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)benzyl acetate

There total 8 articles about 2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-(5-(5-(1-isopropylpiperidin-4-yl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)benzyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1242156-76-8
2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate

: 1360056-62-7
6-chloro-4-(5-(1-isopropylpiperidin-4-yl)pyridin-2-ylamino)-2-methylpyridazin-3(2H)-one

: 1360056-63-8
2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-(5-(5-(1-isopropylpiperidin-4-yl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)benzyl acetate

Guidance literature:: With potassium phosphate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In water; butan-1-ol; at 100 ℃; for 18h; Inert atmosphere;

Reference yield:

: 1231930-22-5
tert-butyl 6-nitropyridine-3′,6′-dihydro-[3,4′-pyridine]-1′(2′H)-carboxylate

: 1360056-63-8
2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-(5-(5-(1-isopropylpiperidin-4-yl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)benzyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / palladium on activated charcoal / ethyl acetate; ethanol / 22 h

2: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 18 h / 90 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 18 h / Inert atmosphere

4: sodium cyanoborohydride; acetic acid / tetrahydrofuran; acetone; methanol / 24 h / Inert atmosphere

5: potassium phosphate / bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos / butan-1-ol; water / 18 h / 100 °C / Inert atmosphere

With potassium phosphate; hydrogen; sodium cyanoborohydride; caesium carbonate; acetic acid; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium on activated charcoal; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate; acetone; butan-1-ol;

Reference yield:

: 1198408-35-3
6-amino-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1'-carboxylic acid tert-butyl ester

: 1360056-63-8
2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-(5-(5-(1-isopropylpiperidin-4-yl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)benzyl acetate

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 18 h / 90 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 18 h / Inert atmosphere

3: sodium cyanoborohydride; acetic acid / tetrahydrofuran; acetone; methanol / 24 h / Inert atmosphere

4: potassium phosphate / bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos / butan-1-ol; water / 18 h / 100 °C / Inert atmosphere

With potassium phosphate; sodium cyanoborohydride; caesium carbonate; acetic acid; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetone; butan-1-ol;