Technology Process of benzoic acid (2R,3S,4R,5R)-2-azido-3,4-dibenzoyloxy-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydrofuran-2-ylmethyl ester
There total 10 articles about benzoic acid (2R,3S,4R,5R)-2-azido-3,4-dibenzoyloxy-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydrofuran-2-ylmethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C30H23N5O9;
With
dmap; 2,4,6-triisopropylphenylsulfonyl chloride; triethylamine;
In
acetonitrile;
at 20 ℃;
for 14h;
With
ammonia;
In
tetrahydrofuran;
at 20 ℃;
for 2h;
benzoyl chloride;
With
pyridine;
at 20 ℃;
for 16h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 15-crown-5 / N,N-dimethyl-formamide / 120 h / 90 - 100 °C
2.1: dmap; 2,4,6-triisopropylphenylsulfonyl chloride; triethylamine / acetonitrile / 14 h / 20 °C
2.2: 2 h / 20 °C
2.3: 16 h / 20 °C
With
dmap; 2,4,6-triisopropylphenylsulfonyl chloride; 15-crown-5; triethylamine;
In
N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: pyridine / 14 h / 0 - 20 °C
2.1: dmap; 2,4,6-triisopropylphenylsulfonyl chloride; triethylamine / acetonitrile / 14 h / 20 °C
2.2: 2 h / 20 °C
2.3: 16 h / 20 °C
With
pyridine; dmap; 2,4,6-triisopropylphenylsulfonyl chloride; triethylamine;
In
acetonitrile;
