benzyl 4-(cyclopropylmethyl)-1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazole-5-carboxylate

Base Information

Chemical Name:benzyl 4-(cyclopropylmethyl)-1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazole-5-carboxylate
CAS No.:1610370-85-8
Molecular Formula:C₃₇H₃₄F₄N₂O₃
Molecular Weight:630.682
Hs Code.:

benzyl 4-(cyclopropylmethyl)-1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazole-5-carboxylate

Synonyms:benzyl 4-(cyclopropylmethyl)-1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazole-5-carboxylate

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Chemical Property of benzyl 4-(cyclopropylmethyl)-1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazole-5-carboxylate

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of benzyl 4-(cyclopropylmethyl)-1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazole-5-carboxylate

There total 11 articles about benzyl 4-(cyclopropylmethyl)-1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1610370-45-0
2,2,2-trifluoro-N'-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)acetohydrazonoyl chloride

: 1610370-38-1
(E)-benzyl 4-cyclopropylbut-2-enoate

: 1610370-85-8
benzyl 4-(cyclopropylmethyl)-1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazole-5-carboxylate

Guidance literature:: With silver carbonate; In 1,4-dioxane; at 70 ℃;

Reference yield:

: 17100-58-2
4-bromo-2-methylbenzyl alcohol

: 1610370-85-8
benzyl 4-(cyclopropylmethyl)-1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazole-5-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

1.2: 12 h / -78 - 20 °C / Inert atmosphere

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 3 h / 66 °C / Inert atmosphere

3.1: toluene-4-sulfonic acid hydrazide / 1,4-dioxane / 0.33 h / 80 °C

3.2: 1.33 h / 90 °C

4.1: caesium carbonate; 1,10-Phenanthroline; copper(l) iodide / N,N-dimethyl-formamide / 1.67 h / 80 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

6.1: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 4.75 h / 760.05 Torr

7.1: benzenesulfonyl chloride; N-ethyl-N,N-diisopropylamine / ethyl acetate / 0 - 20 °C

8.1: silver carbonate / 1,4-dioxane / 70 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,10-Phenanthroline; oxalyl dichloride; 5%-palladium/activated carbon; hydrogen; potassium carbonate; caesium carbonate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; benzenesulfonyl chloride; toluene-4-sulfonic acid hydrazide; silver carbonate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 24078-12-4
4-bromo-2-methylbenzaldehyde

: 1610370-85-8
benzyl 4-(cyclopropylmethyl)-1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazole-5-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 3 h / 66 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid hydrazide / 1,4-dioxane / 0.33 h / 80 °C

2.2: 1.33 h / 90 °C

3.1: caesium carbonate; 1,10-Phenanthroline; copper(l) iodide / N,N-dimethyl-formamide / 1.67 h / 80 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

5.1: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 4.75 h / 760.05 Torr

6.1: benzenesulfonyl chloride; N-ethyl-N,N-diisopropylamine / ethyl acetate / 0 - 20 °C

7.1: silver carbonate / 1,4-dioxane / 70 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,10-Phenanthroline; 5%-palladium/activated carbon; hydrogen; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; benzenesulfonyl chloride; toluene-4-sulfonic acid hydrazide; silver carbonate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;