4-(4-((1-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-1,2,4-triazol-5-yl)methyl)pyridin-2-yl)piperazin-1-ium formate

Base Information

Chemical Name:4-(4-((1-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-1,2,4-triazol-5-yl)methyl)pyridin-2-yl)piperazin-1-ium formate
CAS No.:1570043-45-6
Molecular Formula:CH₂O₂*C₂₂H₂₁F₃N₈O₂
Molecular Weight:532.482
Hs Code.:

Synonyms:4-(4-((1-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-1,2,4-triazol-5-yl)methyl)pyridin-2-yl)piperazin-1-ium formate

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Chemical Property of 4-(4-((1-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-1,2,4-triazol-5-yl)methyl)pyridin-2-yl)piperazin-1-ium formate

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Technology Process of 4-(4-((1-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-1,2,4-triazol-5-yl)methyl)pyridin-2-yl)piperazin-1-ium formate

There total 11 articles about 4-(4-((1-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-1,2,4-triazol-5-yl)methyl)pyridin-2-yl)piperazin-1-ium formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 64-18-6
formic acid

: 1570043-53-6
benzyl 4-(4-((2-methyl-5-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-2H-1,2,4-triazol-3-yl)methyl)pyridin-2-yl)piperazine-1-carboxylate

: 1570043-45-6
4-(4-((1-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-1,2,4-triazol-5-yl)methyl)pyridin-2-yl)piperazin-1-ium formate

Guidance literature:: benzyl 4-(4-((2-methyl-5-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-2H-1,2,4-triazol-3-yl)methyl)pyridin-2-yl)piperazine-1-carboxylate; With water; hydrogen bromide; acetic acid; at 20 - 40 ℃; for 1h;

formic acid; In water; acetonitrile;

Reference yield:

: 873865-81-7
2-chloro-4-((tetrahydro-2H-pyran-2-yloxy)methyl)pyridine

: 1570043-45-6
4-(4-((1-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-1,2,4-triazol-5-yl)methyl)pyridin-2-yl)piperazin-1-ium formate

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine / 48 h / 150 °C

2.1: sodium hydroxide / methanol / 20 °C

3.1: thionyl chloride / dichloromethane / 20 °C

3.2: 20 °C

4.1: dimethyl sulfoxide / 20 °C

5.1: hydrogenchloride / 5 h / 0 °C

6.1: triethylamine / methanol / 3 h / 0 - 80 °C

7.1: water; acetic acid; hydrogen bromide / 1 h / 20 - 40 °C

7.2: Column: XBridge (C₁₈, Sum)

With hydrogenchloride; thionyl chloride; water; hydrogen bromide; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1570043-47-8
benzyl 4-(4-((tetrahydro-2H-pyran-2-yloxy)methyl)pyridin-2-yl)piperazine-1-carboxylate

: 1570043-45-6
4-(4-((1-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-1,2,4-triazol-5-yl)methyl)pyridin-2-yl)piperazin-1-ium formate

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / dichloromethane / 20 °C

1.2: 20 °C

2.1: dimethyl sulfoxide / 20 °C

3.1: hydrogenchloride / 5 h / 0 °C

4.1: triethylamine / methanol / 3 h / 0 - 80 °C

5.1: water; acetic acid; hydrogen bromide / 1 h / 20 - 40 °C

5.2: Column: XBridge (C₁₈, Sum)

With hydrogenchloride; thionyl chloride; water; hydrogen bromide; acetic acid; triethylamine; In methanol; dichloromethane; dimethyl sulfoxide;