{5-[4-(4-fluoromethyl-2-phenyl-4,5-dihydro-oxazol-5-yl)-phenyl]-pyridin-2-yl}-methanol

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Chemical Name:{5-[4-(4-fluoromethyl-2-phenyl-4,5-dihydro-oxazol-5-yl)-phenyl]-pyridin-2-yl}-methanol
CAS No.:1400741-15-2
Molecular Formula:C₂₂H₁₉FN₂O₂
Molecular Weight:362.403
Hs Code.:

Synonyms:{5-[4-(4-fluoromethyl-2-phenyl-4,5-dihydro-oxazol-5-yl)-phenyl]-pyridin-2-yl}-methanol

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Chemical Property of {5-[4-(4-fluoromethyl-2-phenyl-4,5-dihydro-oxazol-5-yl)-phenyl]-pyridin-2-yl}-methanol

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Technology Process of {5-[4-(4-fluoromethyl-2-phenyl-4,5-dihydro-oxazol-5-yl)-phenyl]-pyridin-2-yl}-methanol

There total 9 articles about {5-[4-(4-fluoromethyl-2-phenyl-4,5-dihydro-oxazol-5-yl)-phenyl]-pyridin-2-yl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 88139-91-7
(5-bromopyridin-2-yl)methanol

: 1400741-14-1
4-fluoromethyl-2-phenyl-5-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-4,5-dihydro-oxazole

: 1400741-15-2
{5-[4-(4-fluoromethyl-2-phenyl-4,5-dihydro-oxazol-5-yl)-phenyl]-pyridin-2-yl}-methanol

Guidance literature:: With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; water; toluene; at 90 ℃; for 16h; Inert atmosphere;

Reference yield:

: 119-62-0,716-61-0,2792-51-0,2792-52-1,2964-48-9,3689-55-2,63526-31-8,71115-69-0,140694-64-0
(1R,2R)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol

: 1400741-15-2
{5-[4-(4-fluoromethyl-2-phenyl-4,5-dihydro-oxazol-5-yl)-phenyl]-pyridin-2-yl}-methanol

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydrogencarbonate / water; tetrahydrofuran / 0 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 20 °C

3.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C

3.2: 0 - 20 °C

4.1: sulfuric acid / 18 h / 105 °C

4.2: 20 °C / pH 13

5.1: triethylamine / 1,1-dichloroethane / Reflux

6.1: diethylamino-sulfur trifluoride / dichloromethane / -78 - 20 °C

7.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

7.2: 20 °C

8.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene; ethanol; water / 16 h / 90 °C / Inert atmosphere

With hydrogenchloride; n-butyllithium; diethylamino-sulfur trifluoride; sulfuric acid; hydrogen; sodium hydrogencarbonate; potassium carbonate; triethylamine; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; 1,1-dichloroethane; ethanol; hexane; dichloromethane; water; toluene; 8.1: Suzuki Coupling;

Reference yield:

: 4423-58-9
N-(1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl)acetamide

: 1400741-15-2
{5-[4-(4-fluoromethyl-2-phenyl-4,5-dihydro-oxazol-5-yl)-phenyl]-pyridin-2-yl}-methanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 20 °C

2.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C

2.2: 0 - 20 °C

3.1: sulfuric acid / 18 h / 105 °C

3.2: 20 °C / pH 13

4.1: triethylamine / 1,1-dichloroethane / Reflux

5.1: diethylamino-sulfur trifluoride / dichloromethane / -78 - 20 °C

6.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

6.2: 20 °C

7.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene; ethanol; water / 16 h / 90 °C / Inert atmosphere

With hydrogenchloride; n-butyllithium; diethylamino-sulfur trifluoride; sulfuric acid; hydrogen; potassium carbonate; triethylamine; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; 1,1-dichloroethane; ethanol; hexane; dichloromethane; water; toluene; 7.1: Suzuki Coupling;