8-Bromo-7-hydroxy-2-methyl-6-phenyl-1,4-dihydro-[1,2]diazepino[4,5,6-cd]indol-3-one

Base Information

Chemical Name:8-Bromo-7-hydroxy-2-methyl-6-phenyl-1,4-dihydro-[1,2]diazepino[4,5,6-cd]indol-3-one
CAS No.:77294-45-2
Molecular Formula:C₁₇H₁₂BrN₃O₂
Molecular Weight:370.205
Hs Code.:

Synonyms:8-Bromo-7-hydroxy-2-methyl-6-phenyl-1,4-dihydro-[1,2]diazepino[4,5,6-cd]indol-3-one

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Chemical Property of 8-Bromo-7-hydroxy-2-methyl-6-phenyl-1,4-dihydro-[1,2]diazepino[4,5,6-cd]indol-3-one

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Technology Process of 8-Bromo-7-hydroxy-2-methyl-6-phenyl-1,4-dihydro-[1,2]diazepino[4,5,6-cd]indol-3-one

There total 4 articles about 8-Bromo-7-hydroxy-2-methyl-6-phenyl-1,4-dihydro-[1,2]diazepino[4,5,6-cd]indol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 77294-39-4
Benzoic acid N'-(6-bromo-5-hydroxy-2-methyl-1H-indole-3-carbonyl)-hydrazide

: 77294-45-2
8-Bromo-7-hydroxy-2-methyl-6-phenyl-1,4-dihydro-[1,2]diazepino[4,5,6-cd]indol-3-one

Guidance literature:: With trichlorophosphate; In chloroform; for 3h; Heating;

Reference yield:

: 7598-91-6
ethyl 5-hydroxy-2-methylindole-3-carboxylate

: 77294-45-2
8-Bromo-7-hydroxy-2-methyl-6-phenyl-1,4-dihydro-[1,2]diazepino[4,5,6-cd]indol-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: bromine / acetic acid

2: 85 percent / 80percent N₂H₄*H₂O / ethanol / Heating

3: 86 percent / 10percent aq. NaOH / 12 h / under cooling

4: 76 percent / POCl₃ / CHCl₃ / 3 h / Heating

With sodium hydroxide; bromine; hydrazine hydrate; trichlorophosphate; In ethanol; chloroform; acetic acid;

Reference yield:

: 77294-33-8
6-Bromo-5-hydroxy-2-methyl-1H-indole-3-carboxylic acid hydrazide

: 77294-45-2
8-Bromo-7-hydroxy-2-methyl-6-phenyl-1,4-dihydro-[1,2]diazepino[4,5,6-cd]indol-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / 10percent aq. NaOH / 12 h / under cooling

2: 76 percent / POCl₃ / CHCl₃ / 3 h / Heating

With sodium hydroxide; trichlorophosphate; In chloroform;