Chemical Property of CID 657357
Chemical Property:
- Vapor Pressure:2.94E-11mmHg at 25°C
- Melting Point:223oC
- Boiling Point:528.5 °C at 760 mmHg
- Flash Point:273.4 °C
- PSA：45.78000
- LogP:3.16660
- Storage Temp.:-20°C Freezer
- Solubility.:45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 23.3 mg/m
- Water Solubility.:Soluble at 25mg/ml in methanol. Also soluble in 0.1M HCl or DMSO. Insoluble in water
/n
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:5
- Exact Mass:407.1279658
- Heavy Atom Count:27
- Complexity:611
- Purity/Quality:
-
99%, *data from raw suppliers
Trazodone hydrochloride *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn,
Xi
- Hazard Codes:Xn,Xi,T,F
- Statements:
22-40-36/37/38-39/23/24/25-23/24/25-11
- Safety Statements:
22-36-37/39-26-45-36/37-16-7
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:[H+].C1CN(CCN1CCCN2C(=O)N3C=CC=CC3=N2)C4=CC(=CC=C4)Cl.[Cl-]
-
Description
Trazodone Hydrochloride belongs to the hydrochloride salt form of trazodone with antidepressant and sedative activities, which is primarily used in the treatment of major depression. It serves as a serotonin uptake inhibitor that is effective for patients suffering from major depressive disorders and other subsets of depressive disorders, which is especially helpful for geriatric patients with severe agitation and certain depressive disorders associated with insomnia and anxiety since it has proved that trazodone also has anti-anxiety (anxiolytic) and sleep-inducing (hypnotic) effects. Besides, it is often prescribed as a sedative that is used for the treatment of panic attacks, aggressive behavior, agoraphobia, and cocaine withdrawal in combination with other drugs. Trazodone Hydrochloride is an oral drug that functions by affecting the balance of chemicals (neurotransmitters) within the brain that nerves use to communicate with (stimulate) each other.
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Uses
A serotonin uptake inhibitor antihistamine Monoamine reuptake inhibitor; antidepressant.
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Therapeutic Function
Tranquilizer
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Clinical Use
Tricyclic-related antidepressant
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Drug interactions
Potentially hazardous interactions with other drugs
Alcohol: increased sedative effects.
Antidepressants: avoid concomitant use with
MAOIs and moclobemide.
Antiepileptics: antagonism of anticonvulsant effect;
concentration reduced by carbamazepine.
Antimalarials: manufacturer advises avoid
concomitant use with artemether and lumefantrine
and piperaquine with artenimol.
Antivirals: concentration increased by ritonavir;
increased risk of ventricular arrhythmias with
saquinavir - avoid; concentration possibly increased
by telaprevir.
