2-(3-BroMopropyl)-1,2,4-triazolo-pyridin-3-one

Base Information

• Chemical Name: 2-(3-BroMopropyl)-1,2,4-triazolo-pyridin-3-one
• CAS No.: 1094305-62-0
• Molecular Formula: C₉H₁₀BrN₃O
• Molecular Weight: 256.102
• Mol file: 1094305-62-0.mol

Synonyms:2-(3-BroMopropyl)-1,2,4-triazolo-pyridin-3-one;2-(3-BroMopropyl)-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one

Chemical Property of 2-(3-BroMopropyl)-1,2,4-triazolo-pyridin-3-one

Chemical Property:

• PSA: 39.30000
• LogP: 1.28100
• Solubility.: Chloroform, Diethyl Ether, Ethyl Acetate

Purity/Quality:

2-(3-Bromopropyl)-1,2,4-triazolo-pyridin-3-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(3-BroMopropyl)-1,2,4-triazolo-pyridin-3-one can be used in the preparation of bicycloamine derivatives as sodium channel inhibitors for treatment of pain, epilepsy and insomnia.

Technology Process of 2-(3-BroMopropyl)-1,2,4-triazolo-pyridin-3-one

There total 4 articles about 2-(3-BroMopropyl)-1,2,4-triazolo-pyridin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one (6969-71-7) + 1,3-dibromo-propane (109-64-8) → 2-(3-bromopropyl)[1,2,4]triazolo[4,3-a]pyridine-3(2H)-one (1094305-62-0)

Guidance literature:

With tetrabutylammomium bromide; potassium carbonate; In acetonitrile; for 0.0333333h; Time; Microwave irradiation;

DOI:10.3390/molecules24081609

Reference yield:

2-chloropyridine (109-09-1) → 2-(3-bromopropyl)[1,2,4]triazolo[4,3-a]pyridine-3(2H)-one (1094305-62-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 2-ethoxy-ethanol / 0.03 h / Microwave irradiation

2: potassium carbonate; tetrabutylammomium bromide / acetonitrile / 0.03 h / Microwave irradiation

With sulfuric acid; tetrabutylammomium bromide; potassium carbonate; In 2-ethoxy-ethanol; acetonitrile;

DOI:10.3390/molecules24081609

Reference yield:

2-bromo-pyridine (109-04-6) → 2-(3-bromopropyl)[1,2,4]triazolo[4,3-a]pyridine-3(2H)-one (1094305-62-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 2-ethoxy-ethanol / 0.03 h / Microwave irradiation

2: potassium carbonate; tetrabutylammomium bromide / acetonitrile / 0.03 h / Microwave irradiation

With sulfuric acid; tetrabutylammomium bromide; potassium carbonate; In 2-ethoxy-ethanol; acetonitrile;

DOI:10.3390/molecules24081609

upstream raw materials:

[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

1,3-dibromo-propane

2-chloropyridine

2-bromo-pyridine

Downstream raw materials:

trazodone