(1S)-2-[2-(2,2-dimethyl-6-methylenecyclohexyl)vinyl]-(2R)-5-methoxy-2,7-dimethylchroman

Base Information

Chemical Name:(1S)-2-[2-(2,2-dimethyl-6-methylenecyclohexyl)vinyl]-(2R)-5-methoxy-2,7-dimethylchroman
CAS No.:618120-15-3
Molecular Formula:C₂₃H₃₂O₂
Molecular Weight:340.506
Hs Code.:

Synonyms:(1S)-2-[2-(2,2-dimethyl-6-methylenecyclohexyl)vinyl]-(2R)-5-methoxy-2,7-dimethylchroman

Suppliers and Price of (1S)-2-[2-(2,2-dimethyl-6-methylenecyclohexyl)vinyl]-(2R)-5-methoxy-2,7-dimethylchroman

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S)-2-[2-(2,2-dimethyl-6-methylenecyclohexyl)vinyl]-(2R)-5-methoxy-2,7-dimethylchroman

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (1S)-2-[2-(2,2-dimethyl-6-methylenecyclohexyl)vinyl]-(2R)-5-methoxy-2,7-dimethylchroman

There total 13 articles about (1S)-2-[2-(2,2-dimethyl-6-methylenecyclohexyl)vinyl]-(2R)-5-methoxy-2,7-dimethylchroman which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 593251-76-4
Carbonic acid (Z)-5-(2-hydroxy-6-methoxy-4-methyl-phenyl)-3-methyl-pent-2-enyl ester methyl ester

: 618120-15-3
(1S)-2-[2-(2,2-dimethyl-6-methylenecyclohexyl)vinyl]-(2R)-5-methoxy-2,7-dimethylchroman

Guidance literature:: Multi-step reaction with 5 steps

1.1: 0.852 g / Pd₂(dba)3*CHCl₃; acetic acid; (S,S)-cyclohexane-[1,2-di(NH-CO-Ph(2-PPh₂)] / CH₂Cl₂ / 1 h / 20 °C

2.1: N-methylmorpholine-N-oxide; aq. OsO₄ / CH₂Cl₂ / 5 h / 20 °C

2.2: 94 percent / aq. NaIO₄ / acetone / 0.33 h / 20 °C

3.1: n-BuLi / tetrahydrofuran; hexane / 0.67 h / -78 °C

3.2: tetrahydrofuran; hexane / 3 h / -78 - 20 °C

4.1: n-BuLi; 1,10-phenantroline / tetrahydrofuran; hexane / 0.17 h / -78 °C

4.2: tetrahydrofuran; hexane / 10 h / 20 °C

5.1: 0.775 g / Na(Hg); Na₂HPO₄ / methanol / 0.83 h / 0 °C

With trans-1,2-(1S,2S)-1,2-diaminocyclohexane-N,N’-bis(2’-diphenylphosphinobenzoyl); tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; disodium hydrogenphosphate; osmium(VIII) oxide; n-butyllithium; 1,10-Phenanthroline; sodium amalgam; acetic acid; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; hexane; dichloromethane; 3.2: Julia olefination;
DOI:10.1021/ja048084p

Reference yield:

: Acetic acid 1-((S)-2,2-dimethyl-6-methylene-cyclohexyl)-2-((R)-5-methoxy-2,7-dimethyl-chroman-2-yl)-ethyl ester

: 618120-15-3
(1S)-2-[2-(2,2-dimethyl-6-methylenecyclohexyl)vinyl]-(2R)-5-methoxy-2,7-dimethylchroman

Guidance literature:: With disodium hydrogenphosphate; sodium amalgam; In methanol; at 0 ℃; for 0.833333h;
DOI:10.1021/ja048084p

Reference yield:

: 593251-63-9
(E)-5-(2-hydroxy-6-methoxyphenyl)-3-methylpent-2-enyl methyl carbonate

: 618120-15-3
(1S)-2-[2-(2,2-dimethyl-6-methylenecyclohexyl)vinyl]-(2R)-5-methoxy-2,7-dimethylchroman

Guidance literature:: Multi-step reaction with 6 steps

1: (R,R)-1,2-bis[2-(diphenylphosphino)benzamido]cyclohexane; HOAc / [Pd₂(dibenzylideneacetone)3*CHCl₃] / CH₂Cl₂ / 1 h / 20 °C

2: OsO₄; N-methylmorpholine N-oxide / CH₂Cl₂; H₂O

3: NaIO₄ / acetone; H₂O

4: n-BuLi

5: n-BuLi

6: Na(Hg); Na₂HPO₄

With sodium periodate; disodium hydrogenphosphate; osmium(VIII) oxide; n-butyllithium; sodium amalgam; acetic acid; 4-methylmorpholine N-oxide; (1R,2R)-1,2-bis[(2-diphenylphosphanyl)benzoylamino]cyclohexane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In dichloromethane; water; acetone;
DOI:10.1002/anie.200351868