(1S,2S)-1-hydroxymethyl-2-[(2S)-2-(5-methoxy-2,7-dimethyl-2H-chromen-2-yl)ethyl]-3,3-dimethylcyclohexanol

Base Information

• Chemical Name: (1S,2S)-1-hydroxymethyl-2-[(2S)-2-(5-methoxy-2,7-dimethyl-2H-chromen-2-yl)ethyl]-3,3-dimethylcyclohexanol
• CAS No.: 618120-18-6
• Molecular Formula: C₂₃H₃₄O₄
• Molecular Weight: 374.521
• Mol file: 618120-18-6.mol

Synonyms:(1S,2S)-1-hydroxymethyl-2-[(2S)-2-(5-methoxy-2,7-dimethyl-2H-chromen-2-yl)ethyl]-3,3-dimethylcyclohexanol

Chemical Property of (1S,2S)-1-hydroxymethyl-2-[(2S)-2-(5-methoxy-2,7-dimethyl-2H-chromen-2-yl)ethyl]-3,3-dimethylcyclohexanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (1S,2S)-1-hydroxymethyl-2-[(2S)-2-(5-methoxy-2,7-dimethyl-2H-chromen-2-yl)ethyl]-3,3-dimethylcyclohexanol

There total 32 articles about (1S,2S)-1-hydroxymethyl-2-[(2S)-2-(5-methoxy-2,7-dimethyl-2H-chromen-2-yl)ethyl]-3,3-dimethylcyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(2S)-1-hydroxymethyl-2-[(2S)-2-(5-methoxy-2,7-dimethylchroman-2-yl)ethyl]-3,3-dimethylcyclohexanol → (1S,2S)-1-hydroxymethyl-2-[(2S)-2-(5-methoxy-2,7-dimethyl-2H-chromen-2-yl)ethyl]-3,3-dimethylcyclohexanol (618120-18-6)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone;

DOI:10.1002/anie.200351868

Reference yield: 65.0%

methyl iodide (74-88-4) + (+)-siccanochromene F (35334-36-2) → (1S,2S)-1-hydroxymethyl-2-[(2S)-2-(5-methoxy-2,7-dimethyl-2H-chromen-2-yl)ethyl]-3,3-dimethylcyclohexanol (618120-18-6)

Guidance literature:

(+)-siccanochromene F; With caesium carbonate; In N,N-dimethyl-formamide; for 0.25h;

methyl iodide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.5h;

DOI:10.1002/ejoc.201500208

Reference yield: 63.0%

(1S,2S)-1-(hydroxymethyl)-2-(2-((2S)-5-methoxy-2,7-dimethylchroman-2-yl)ethyl)-3,3-dimethylcyclohexan-1-ol → (1S,2S)-1-hydroxymethyl-2-[(2S)-2-(5-methoxy-2,7-dimethyl-2H-chromen-2-yl)ethyl]-3,3-dimethylcyclohexanol (618120-18-6)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In benzene; at 80 ℃; for 2h;

DOI:10.1055/s-0035-1560752

upstream raw materials:

(S)-(+)-(2',2'-dimethyl-6'-methylene-1'-cyclohexyl)methanol

(S)-(-)-2,2-dimethyl-6-methylene-1-[1'-(phenylthio)methyl]cyclohexane

(S)-1-[1′-benzenesulfonyl]methyl-2,2-dimehtyl-6-methylenecyclohexane

(R)-5-methoxy-2,7-dimethylchroman-2-carboxyaldehyde

Downstream raw materials:

Toluene-4-sulfonic acid (1S,2S)-1-hydroxy-2-[2-((S)-5-methoxy-2,7-dimethyl-2H-chromen-2-yl)-ethyl]-3,3-dimethyl-cyclohexylmethyl ester

siccanin