Technology Process of 7-benzyloxy-3-butyl-1-ethyl-3,5-dimethyl-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione
There total 6 articles about 7-benzyloxy-3-butyl-1-ethyl-3,5-dimethyl-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
7-benzyloxy-1-ethyl-3,5-dimethyl-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione;
With
sodium hydride;
In
N,N-dimethyl-formamide; oil;
at 0 ℃;
for 0.5h;
1-iodo-butane;
In
N,N-dimethyl-formamide; oil;
at 0 - 20 ℃;
for 2.5h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate; tetrabutyl-ammonium chloride / toluene / 3.5 h / Reflux
2.1: toluene / 3 h / 50 - 80 °C
3.1: hydrogen; diphenyl sulfide / palladium 10% on activated carbon / water; methanol / 20 °C
3.2: 20 °C
3.3: 1 h
4.1: sodium hydroxide; tetrabutylammomium bromide / toluene; water / 4 h / 80 °C
5.1: sodium t-butanolate / 1,2-dimethoxyethane / 0.5 h / Cooling with ice
5.2: 2 h / Cooling with ice
6.1: sodium hydride / N,N-dimethyl-formamide; oil / 0.5 h / 0 °C
6.2: 2.5 h / 0 - 20 °C
With
diphenyl sulfide; tetrabutylammomium bromide; tetrabutyl-ammonium chloride; hydrogen; sodium hydride; potassium carbonate; sodium hydroxide; sodium t-butanolate;
palladium 10% on activated carbon;
In
methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; toluene; oil;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: toluene / 3 h / 50 - 80 °C
2.1: hydrogen; diphenyl sulfide / palladium 10% on activated carbon / water; methanol / 20 °C
2.2: 20 °C
2.3: 1 h
3.1: sodium t-butanolate / N,N-dimethyl-formamide / 0.5 h / Cooling with ice
3.2: 6 h / Cooling ice
4.1: sodium t-butanolate / 1,2-dimethoxyethane / 0.5 h / Cooling with ice
4.2: 2 h / Cooling with ice
5.1: sodium hydride / N,N-dimethyl-formamide; oil / 0.5 h / 0 °C
5.2: 2.5 h / 0 - 20 °C
With
diphenyl sulfide; hydrogen; sodium hydride; sodium t-butanolate;
palladium 10% on activated carbon;
In
methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; toluene; oil;
