Benzenamine, 5-fluoro-N-methyl-2-nitro-

Base Information

• Chemical Name: Benzenamine, 5-fluoro-N-methyl-2-nitro-
• CAS No.: 120381-42-2
• Molecular Formula: C7H7FN2O2
• Molecular Weight: 170.143
• Hs Code.: 2921430090
• Mol file: 120381-42-2.mol

Synonyms:.5-fluoro-N-2-methyl-2-nitroaniline;.(5-fluoro-2-nitrophenyl)methylamine;5-fluoro-N-methyl-2-nitroaniline;

Chemical Property of Benzenamine, 5-fluoro-N-methyl-2-nitro-

Chemical Property:

• Boiling Point: 282.8±30.0 °C(Predicted)
• PKA: -1.22±0.25(Predicted)
• PSA: 57.85000
• Density: 1.361±0.06 g/cm3(Predicted)
• LogP: 2.37180
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

5-Fluoro-N-methyl-2-nitroaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 5-Fluoro-N-methyl-2-nitroaniline acts as a reagent in the preparation of 2-aminobenzimidazoles as Raf kinase inhibitors. Synthesis and structure-activity relationship of novel, selective, orally bioavailable positive modulators of mGluR2.

Technology Process of Benzenamine, 5-fluoro-N-methyl-2-nitro-

There total 4 articles about Benzenamine, 5-fluoro-N-methyl-2-nitro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,4-Difluoronitrobenzene (446-35-5) + methylamine (74-89-5) → 4-fluoro-2-methylaminonitrobenzene (120381-42-2)

Guidance literature:

In tetrahydrofuran; water; at 20 ℃; for 4h;

Reference yield:

2,2,2-trifluoro-N-(5-fluoro-2-nitrophenyl)acetamide + dimethyl sulfate (77-78-1) → 4-fluoro-2-methylaminonitrobenzene (120381-42-2)

Guidance literature:

With sodium hydroxide; benzyltrimethylammonium chloride; In water; toluene; acetonitrile; at 20 ℃;

Reference yield:

2,4-Difluoronitrobenzene (446-35-5) → 4-fluoro-2-methylaminonitrobenzene (120381-42-2)

Guidance literature:

With methylamine;

upstream raw materials:

dimethyl sulfate

2,4-Difluoronitrobenzene

5-fluoro-2-nitroaniline

methylamine

Downstream raw materials:

N-methyl{4-[3-(methylamino)-4-nitro-phenoxy](2-pyridyl)}carboxamide

5-[(2-methoxypyridin-4-yl)oxy]-N-methyl-2-nitroaniline

6-fluoro-1-methyl-1H-benzo[d]imidazole

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