11-<4-<2-(1-piperidinyl)ethoxy>phenyl>-11H-benzofluoren-3-ol

Base Information

• Chemical Name: 11-<4-<2-(1-piperidinyl)ethoxy>phenyl>-11H-benzo
• Molecular Formula: C₃₀H₂₉NO₂
• Molecular Weight: 435.566

Synonyms:11-<4-<2-(1-piperidinyl)ethoxy>phenyl>-11H-benzofluoren-3-ol

Chemical Property of 11-<4-<2-(1-piperidinyl)ethoxy>phenyl>-11H-benzo

Chemical Property:

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There total 9 articles about 11-<4-<2-(1-piperidinyl)ethoxy>phenyl>-11H-benzofluoren-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3-methoxy-11-<4-<2-(1-piperidinyl)ethoxy>phenyl>-11H-benzofluorene (138630-80-5) → 11-<4-<2-(1-piperidinyl)ethoxy>phenyl>-11H-benzofluoren-3-ol (145410-91-9)

Guidance literature:

With aluminium trichloride; ethanethiol; In 1,2-dichloro-ethane; at 0 ℃; for 2.5h;

DOI:10.1021/jm00083a019

Reference yield:

phenyl 4-methoxybenzoate (4181-97-9) → 11-<4-<2-(1-piperidinyl)ethoxy>phenyl>-11H-benzofluoren-3-ol (145410-91-9)

Guidance literature:

Multi-step reaction with 7 steps

1: 57 percent / NaH / tetrahydrofuran / 2.5 h / 20 - 60 °C

2: 83 percent / 4-(dimethylamino)pyridine, triethylamine / CH₂Cl₂

3: tetrahydrofuran; diethyl ether / 1 h / 0 °C

4: 64 percent / EtSH, n-BuLi / tetrahydrofuran; dimethylformamide / 2.5 h / 80 °C

5: 70 percent / methanesulfonic acid / 16 h / Ambient temperature

6: 82 percent / K₂CO₃ / dimethylformamide / 1 h / Heating

7: 87 percent / AlCl₃, EtSH / 1,2-dichloro-ethane / 2.5 h / 0 °C

With dmap; n-butyllithium; aluminium trichloride; methanesulfonic acid; sodium hydride; potassium carbonate; triethylamine; ethanethiol; In tetrahydrofuran; diethyl ether; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00083a019

Reference yield:

N-chloroethylpiperidine hydrochloride (2008-75-5) → 11-<4-<2-(1-piperidinyl)ethoxy>phenyl>-11H-benzofluoren-3-ol (145410-91-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / K₂CO₃ / dimethylformamide / 1 h / Heating

2: 87 percent / AlCl₃, EtSH / 1,2-dichloro-ethane / 2.5 h / 0 °C

With aluminium trichloride; potassium carbonate; ethanethiol; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00083a019

upstream raw materials:

3-methoxy-11-<4-<2-(1-piperidinyl)ethoxy>phenyl>-11H-benzofluorene

phenyl 4-methoxybenzoate

N-chloroethylpiperidine hydrochloride

4-(3-methoxy-11H-benzofluoren-11-yl)phenol

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