4--1-(phenylmethyl)-2-pyrrolidinone

Base Information

• Chemical Name: 4--1-(phenylmethyl)-2-pyrrolidinone
• CAS No.: 117022-79-4
• Molecular Formula: C₂₄H₂₁F₂NO₂
• Molecular Weight: 393.433
• Mol file: 117022-79-4.mol

Synonyms:4--1-(phenylmethyl)-2-pyrrolidinone

Chemical Property of 4--1-(phenylmethyl)-2-pyrrolidinone

Chemical Property:

Purity/Quality:

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Technology Process of 4--1-(phenylmethyl)-2-pyrrolidinone

There total 1 articles about 4--1-(phenylmethyl)-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate (51535-00-3) + 1-Bromo-4-fluorobenzene (460-00-4) → 4--1-(phenylmethyl)-2-pyrrolidinone (117022-79-4)

Guidance literature:

With magnesium; Yield given. Multistep reaction; 1) THF, reflux, 15 min; 2) THF, room temperature, overnight;

DOI:10.1021/jm00121a022

Reference yield: 81.0%

4--1-(phenylmethyl)-2-pyrrolidinone (117022-79-4) → α,α-bis(4-fluorophenyl)-1-(phenylmethyl)-3-pyrrolidinemethanol (117022-72-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Heating;

DOI:10.1021/jm00121a022

Reference yield:

4--1-(phenylmethyl)-2-pyrrolidinone (117022-79-4) → α,α-bis(4-fluorophenyl)-3-pyrrolidinemethanol (117022-73-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / LiAlH₄ / tetrahydrofuran / 2 h / Heating

2: 91 percent / H₂ / 5percent Pd/C / ethanol / 70 °C / 2585.7 Torr

With lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol;

DOI:10.1021/jm00121a022

upstream raw materials:

methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate

1-Bromo-4-fluorobenzene

Downstream raw materials:

α,α-bis(4-fluorophenyl)-1-(phenylmethyl)-3-pyrrolidinemethanol

α,α-bis(4-fluorophenyl)-3-pyrrolidinemethanol

1-[4-[3-[3-[bis(4-fluorophenyl)hydroxymethyl]-1-pyrrolidinyl]propoxy]-3-methoxyphenyl]ethanone