5-(3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)-3-(6-phenylpyridin-3-yl)-8,9-dihydropyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-6(7H)-one

Base Information

Chemical Name:5-(3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)-3-(6-phenylpyridin-3-yl)-8,9-dihydropyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-6(7H)-one
CAS No.:1361297-75-7
Molecular Formula:C₂₇H₂₆N₆O₂
Molecular Weight:466.542
Hs Code.:

Synonyms:5-(3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)-3-(6-phenylpyridin-3-yl)-8,9-dihydropyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-6(7H)-one

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Chemical Property of 5-(3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)-3-(6-phenylpyridin-3-yl)-8,9-dihydropyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-6(7H)-one

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Technology Process of 5-(3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)-3-(6-phenylpyridin-3-yl)-8,9-dihydropyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-6(7H)-one

There total 13 articles about 5-(3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)-3-(6-phenylpyridin-3-yl)-8,9-dihydropyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-6(7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1319256-94-4
tert-butyl 7-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(1-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yI)-3-oxa-9-azabicyclo[3.3.1]nonane-9-carboxylate

: 1361297-75-7
5-(3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)-3-(6-phenylpyridin-3-yl)-8,9-dihydropyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-6(7H)-one

Guidance literature:: With trifluoroacetic acid; at 20 ℃; for 16h;

Reference yield:

: 57489-70-0
5,7-dihydroxypyrazolo[1,5-a]pyrimidine

: 1361297-75-7
5-(3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)-3-(6-phenylpyridin-3-yl)-8,9-dihydropyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-6(7H)-one

Guidance literature:: Multi-step reaction with 10 steps

1.1: trichlorophosphate; N,N-dimethyl-aniline / 16 h / 0 - 60 °C / Inert atmosphere

1.2: pH ~ 8

2.1: ammonium hydroxide / 2.5 h / 85 °C / Sealed vessel

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 45 °C

4.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 16 h / 100 °C

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 16 h / 50 °C

6.1: N-iodo-succinimide / acetonitrile / 0.5 h / 20 °C

7.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 16 h / 100 °C / Inert atmosphere

8.1: N-Bromosuccinimide / acetonitrile / 0.5 h / 20 °C

9.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

10.1: trifluoroacetic acid / 16 h / 20 °C

With ammonium hydroxide; N-Bromosuccinimide; N-iodo-succinimide; hydrogen; sodium carbonate; potassium carbonate; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; acetonitrile;

Reference yield:

: 280761-97-9
tert-butyl 7-oxo-3-oxa-9-azabicyclo[3.3.1]nonane-9-carboxylate

: 1361297-75-7
5-(3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)-3-(6-phenylpyridin-3-yl)-8,9-dihydropyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-6(7H)-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.08 h / -78 °C

1.2: -78 - 20 °C

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,1'-bis-(diphenylphosphino)ferrocene / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere

3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 16 h / 100 °C

4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 16 h / 50 °C

5.1: N-iodo-succinimide / acetonitrile / 0.5 h / 20 °C

6.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 16 h / 100 °C / Inert atmosphere

7.1: N-Bromosuccinimide / acetonitrile / 0.5 h / 20 °C

8.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

9.1: trifluoroacetic acid / 16 h / 20 °C

With N-Bromosuccinimide; N-iodo-succinimide; hydrogen; potassium acetate; sodium carbonate; potassium carbonate; trifluoroacetic acid; lithium diisopropyl amide; 1,1'-bis-(diphenylphosphino)ferrocene; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water; ethyl acetate; acetonitrile;