6-benzyl-3-[4-(benzyloxy)benzoyl]-1-(ethoxymethyl)-5-isopropyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

Base Information

• Chemical Name: 6-benzyl-3-[4-(benzyloxy)benzoyl]-1-(ethoxymethyl)-5-isopropyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
• CAS No.: 847995-32-8
• Molecular Formula: C₃₁H₃₂N₂O₅
• Molecular Weight: 512.605

Synonyms:6-benzyl-3-[4-(benzyloxy)benzoyl]-1-(ethoxymethyl)-5-isopropyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

Chemical Property of 6-benzyl-3-[4-(benzyloxy)benzoyl]-1-(ethoxymethyl)-5-isopropyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

Chemical Property:

Purity/Quality:

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Technology Process of 6-benzyl-3-[4-(benzyloxy)benzoyl]-1-(ethoxymethyl)-5-isopropyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

There total 2 articles about 6-benzyl-3-[4-(benzyloxy)benzoyl]-1-(ethoxymethyl)-5-isopropyl-1,2,3,4-tetrahydropyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(benzyloxy)benzoic acid chloride (1486-50-6) + Emivirine (149950-60-7) → 6-benzyl-3-[4-(benzyloxy)benzoyl]-1-(ethoxymethyl)-5-isopropyl-1,2,3,4-tetrahydropyrimidine-2,4-dione (847995-32-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In pyridine; at 0 - 20 ℃;

DOI:10.1021/jm040845b

Reference yield:

p-(benzyloxy)benzoic acid (1486-51-7) → 6-benzyl-3-[4-(benzyloxy)benzoyl]-1-(ethoxymethyl)-5-isopropyl-1,2,3,4-tetrahydropyrimidine-2,4-dione (847995-32-8)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂; DMF / Heating

2: 1.77 g / diisopropylethylamine / pyridine / 0 - 20 °C

With thionyl chloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In pyridine;

DOI:10.1021/jm040845b

Reference yield:

6-benzyl-3-[4-(benzyloxy)benzoyl]-1-(ethoxymethyl)-5-isopropyl-1,2,3,4-tetrahydropyrimidine-2,4-dione (847995-32-8) → 6-benzyl-1-ethoxymethyl-3-(4-hydroxy-benzoyl)-5-isopropyl-1H-pyrimidine-2,4-dione (1026149-96-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 1.5h;

DOI:10.1021/jm040845b

upstream raw materials:

4-(benzyloxy)benzoic acid chloride

Emivirine

p-(benzyloxy)benzoic acid

Downstream raw materials:

6-benzyl-1-ethoxymethyl-3-(4-hydroxy-benzoyl)-5-isopropyl-1H-pyrimidine-2,4-dione

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