2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-O⁶-<2-(4-nitrophenyl)ethyl>-N²-phthaloylguanosine

Base Information

• Chemical Name: 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-O⁶-<2-(4-nitrophenyl)ethyl>-N²-phthaloylguanosine
• CAS No.: 199800-59-4
• Molecular Formula: C₄₇H₄₀N₆O₁₀
• Molecular Weight: 848.869

Synonyms:2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-O⁶-<2-(4-nitrophenyl)ethyl>-N²-phthaloylguanosine

Chemical Property of 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-O⁶-<2-(4-nitrophenyl)ethyl>-N²-phthaloylguanosine

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-O⁶-<2-(4-nitrophenyl)ethyl>-N²-phthaloylguanosine

There total 7 articles about 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-O⁶-<2-(4-nitrophenyl)ethyl>-N²-phthaloylguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + 2'-deoxy-O6-<2-(4-nitrophenyl)ethyl>-N2-phthaloylguanosine (199800-46-9) → 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-O6-<2-(4-nitrophenyl)ethyl>-N2-phthaloylguanosine (199800-59-4)

Guidance literature:

DOI:10.1080/07328319708006240

Reference yield:

2'-deoxy-O6-<2-(4-nitrophenyl)ethyl>guanosine (86137-72-6) → 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-O6-<2-(4-nitrophenyl)ethyl>-N2-phthaloylguanosine (199800-59-4)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / 0.5 h

2: pyridine / dioxane / 2.25 h

3: pyridine/H₂O / dioxane / 0.25 h

4: 67 percent / pyridine / 3 h

With pyridine; water; In 1,4-dioxane;

DOI:10.1002/(SICI)1522-2675(19990407)82:4<633::AID-HLCA633>3.0.CO;2-U

Reference yield:

2-amino-6-(2-(p-nitrophenyl)ethyloxy)-9-[2'-deoxy-β-D-erythropentofuranosyl]purine diacetate (108310-92-5) → 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-O6-<2-(4-nitrophenyl)ethyl>-N2-phthaloylguanosine (199800-59-4)

Guidance literature:

Multi-step reaction with 5 steps

1: NaCN / methanol

2: pyridine / 0.5 h

3: pyridine / dioxane / 2.25 h

4: pyridine/H₂O / dioxane / 0.25 h

5: 67 percent / pyridine / 3 h

With pyridine; sodium cyanide; water; In 1,4-dioxane; methanol;

DOI:10.1002/(SICI)1522-2675(19990407)82:4<633::AID-HLCA633>3.0.CO;2-U

upstream raw materials:

4,4'-dimethoxytrityl chloride

2'-deoxy-O⁶-<2-(4-nitrophenyl)ethyl>-N²-phthaloylguanosine

2'-deoxy-O⁶-<2-(4-nitrophenyl)ethyl>guanosine

2-amino-6-(2-(p-nitrophenyl)ethyloxy)-9-[2'-deoxy-β-D-erythropentofuranosyl]purine diacetate

Downstream raw materials:

(2R,3S,5R)-5-{2-Amino-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-ol

5'-O-(p,p'-dimethoxytrityl)-2'-deoxyguanosine

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