Technology Process of 2-(7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-9-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid
There total 18 articles about 2-(7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-9-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl 2-(7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-9-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate;
With
water; lithium hydroxide;
In
dioxanes;
at 75 ℃;
for 16h;
With
hydrogenchloride;
In
dioxanes; water; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: sodium hydride / toluene; mineral oil / 0.83 h
1.2: 20 - 70 °C
1.3: 24 h / Reflux
2.1: tetrahydrofuran / 24 h / Reflux
3.1: hydrogen / palladium 10% on activated carbon / water; tetrahydrofuran / 24 h / 11636.1 Torr
4.1: hydrogen; acetic acid / 20 % Pd(OH)2/C / ethanol; tetrahydrofuran / 50 °C / 10343.2 - 25858.1 Torr
5.1: palladium on carbon / toluene / 48 h / 80 °C
6.1: caesium carbonate / ISOPROPYLAMIDE / 16 h / 80 °C
7.1: N-iodo-succinimide / dichloromethane / 0.08 h / 0 °C
8.1: bis(tri-t-butylphosphine)palladium(0) / tetrahydrofuran / Inert atmosphere
9.1: water; lithium hydroxide / dioxanes / 16 h / 75 °C
With
N-iodo-succinimide; water; hydrogen; sodium hydride; caesium carbonate; acetic acid; lithium hydroxide;
bis(tri-t-butylphosphine)palladium(0); 20 % Pd(OH)2/C; palladium on carbon; palladium 10% on activated carbon;
In
tetrahydrofuran; dioxanes; ethanol; dichloromethane; ISOPROPYLAMIDE; water; toluene; mineral oil;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: caesium carbonate / ISOPROPYLAMIDE / 16 h / 80 °C
2.1: lithium aluminium tetrahydride / dichloromethane / 16 h / -78 - 20 °C / Inert atmosphere
2.2: 0 °C
3.1: thionyl chloride / toluene / 3 h / 75 °C
4.1: caesium carbonate / ISOPROPYLAMIDE / 16 h / 80 °C
5.1: N-iodo-succinimide / dichloromethane / 0.08 h / 0 °C
6.1: bis(tri-t-butylphosphine)palladium(0) / tetrahydrofuran / Inert atmosphere
7.1: water; lithium hydroxide / dioxanes / 16 h / 75 °C
With
N-iodo-succinimide; lithium aluminium tetrahydride; thionyl chloride; water; caesium carbonate; lithium hydroxide;
bis(tri-t-butylphosphine)palladium(0);
In
tetrahydrofuran; dioxanes; dichloromethane; ISOPROPYLAMIDE; toluene;
![tert-butyl 2-(7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-9-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate](/Databaselist/images/loading.webp)
