tert-butyl 2-(7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-9-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

Base Information

Chemical Name:tert-butyl 2-(7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-9-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate
CAS No.:1215118-98-1
Molecular Formula:C₂₉H₃₄F₃NO₄
Molecular Weight:517.588
Hs Code.:

Synonyms:tert-butyl 2-(7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-9-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

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Chemical Property of tert-butyl 2-(7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-9-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

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Technology Process of tert-butyl 2-(7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-9-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

There total 17 articles about tert-butyl 2-(7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-9-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1215118-97-0
tert-butyl 2-(9-iodo-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

: 544-97-8
dimethyl zinc(II)

: 1215118-98-1
tert-butyl 2-(7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-9-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

Guidance literature:: bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; Inert atmosphere;

Reference yield:

: 37033-95-7
5-benzyloxy-1H-indole-2-carboxylic acid ethyl ester

: 1215118-98-1
tert-butyl 2-(7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-9-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / toluene; mineral oil / 0.83 h

1.2: 20 - 70 °C

1.3: 24 h / Reflux

2.1: tetrahydrofuran / 24 h / Reflux

3.1: hydrogen / palladium 10% on activated carbon / water; tetrahydrofuran / 24 h / 11636.1 Torr

4.1: hydrogen; acetic acid / 20 % Pd(OH)2/C / ethanol; tetrahydrofuran / 50 °C / 10343.2 - 25858.1 Torr

5.1: palladium on carbon / toluene / 48 h / 80 °C

6.1: caesium carbonate / ISOPROPYLAMIDE / 16 h / 80 °C

7.1: N-iodo-succinimide / dichloromethane / 0.08 h / 0 °C

8.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾ / tetrahydrofuran / Inert atmosphere

With N-iodo-succinimide; hydrogen; sodium hydride; caesium carbonate; acetic acid; bis(tri-t-butylphosphine)palladium⁽⁰⁾; 20 % Pd(OH)2/C; palladium on carbon; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; ISOPROPYLAMIDE; water; toluene; mineral oil;

Reference yield:

: 220239-68-9
4-hydroxy-3-(trifluoromethyl)benzoic acid

: 1215118-98-1
tert-butyl 2-(7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-9-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / ISOPROPYLAMIDE / 16 h / 80 °C

2.1: lithium aluminium tetrahydride / dichloromethane / 16 h / -78 - 20 °C / Inert atmosphere

2.2: 0 °C

3.1: thionyl chloride / toluene / 3 h / 75 °C

4.1: caesium carbonate / ISOPROPYLAMIDE / 16 h / 80 °C

5.1: N-iodo-succinimide / dichloromethane / 0.08 h / 0 °C

6.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾ / tetrahydrofuran / Inert atmosphere

With N-iodo-succinimide; lithium aluminium tetrahydride; thionyl chloride; caesium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; ISOPROPYLAMIDE; toluene;