5-(4-dimethylaminophenyl)-3-phenyl-4,5-dihydropyrazol-1-carbothioic acid amide

Base Information

• Chemical Name: 5-(4-dimethylaminophenyl)-3-phenyl-4,5-dihydropyrazol-1-carbothioic acid amide
• CAS No.: 1022989-92-9
• Molecular Formula: C₁₈H₂₀N₄S
• Molecular Weight: 324.45

Synonyms:5-(4-dimethylaminophenyl)-3-phenyl-4,5-dihydropyrazol-1-carbothioic acid amide

Chemical Property of 5-(4-dimethylaminophenyl)-3-phenyl-4,5-dihydropyrazol-1-carbothioic acid amide

Chemical Property:

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Technology Process of 5-(4-dimethylaminophenyl)-3-phenyl-4,5-dihydropyrazol-1-carbothioic acid amide

There total 3 articles about 5-(4-dimethylaminophenyl)-3-phenyl-4,5-dihydropyrazol-1-carbothioic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

thiosemicarbazide (79-19-6) + 4-dimethylamino-chalcone (1030-27-9,22965-98-6,72758-79-3) → 5-(4-dimethylaminophenyl)-3-phenyl-4,5-dihydropyrazol-1-carbothioic acid amide (1022989-92-9)

Guidance literature:

With triethylamine; In ethanol; for 2h; Heating;

DOI:10.1080/10426500701242145

Reference yield:

acetophenone (98-86-2) → 5-(4-dimethylaminophenyl)-3-phenyl-4,5-dihydropyrazol-1-carbothioic acid amide (1022989-92-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol; water / 3 - 4 h / 25 °C

2: sodium hydroxide / ethanol; water / 8 h / Reflux

With sodium hydroxide; In ethanol; water;

DOI:10.1080/00958972.2013.773318

Reference yield:

4-dimethylamino-benzaldehyde (100-10-7) → 5-(4-dimethylaminophenyl)-3-phenyl-4,5-dihydropyrazol-1-carbothioic acid amide (1022989-92-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol; water / 3 - 4 h / 25 °C

2: sodium hydroxide / ethanol; water / 8 h / Reflux

With sodium hydroxide; In ethanol; water;

DOI:10.1080/00958972.2013.773318

upstream raw materials:

thiosemicarbazide

4-dimethylamino-chalcone

acetophenone

4-dimethylamino-benzaldehyde

Downstream raw materials:

N,N-dimethyl-4-[1-(4-methyl-thiazol-2-yl)-3-phenyl(2-pyrazolin-5-yl)]phenylamine

{2-[5-(4-dimethylaminophenyl)-3-phenyl-4,5-dihydropyrazol-1-yl]-4-oxo-4,5-dihydrothiazol-5-yl}-acetic acid

5-chloro-3-{2-[5-(4-dimethylaminophenyl)-3-phenyl-4,5-dihydropyrazol-1-yl]-4-oxo-4,5-dihydro-1,3-thiazol-5-ylidene}-2,3-dihydro-1H-indol-2-one

5-bromo-3-{2-[5-(4-dimethylaminophenyl)-3-phenyl-4,5-dihydropyrazol-1-yl]-4-oxo-4,5-dihydro-1,3-thiazol-5-ylidene}-2,3-dihydro-1H-indol-2-one

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