diethyl 2-acetamido-2-(4-(benzyloxy)phenethyl)malonate

Base Information

Chemical Name:diethyl 2-acetamido-2-(4-(benzyloxy)phenethyl)malonate
CAS No.:209476-18-6
Molecular Formula:C₂₄H₂₉NO₆
Molecular Weight:427.497
Hs Code.:

Synonyms:diethyl 2-acetamido-2-(4-(benzyloxy)phenethyl)malonate

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Chemical Property of diethyl 2-acetamido-2-(4-(benzyloxy)phenethyl)malonate

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Technology Process of diethyl 2-acetamido-2-(4-(benzyloxy)phenethyl)malonate

There total 7 articles about diethyl 2-acetamido-2-(4-(benzyloxy)phenethyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 163930-30-1
2-<4-(Benzyloxy)phenyl>ethyl iodide

: 209476-18-6
diethyl 2-acetamido-2-(4-(benzyloxy)phenethyl)malonate

Guidance literature:: 2-acetylaminomalonic acid diethyl ester; With sodium hydride; In DMF (N,N-dimethyl-formamide); at 0 ℃; for 3h;

2-<4-(Benzyloxy)phenyl>ethyl iodide; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃; Product distribution / selectivity;

Reference yield: 63.0%

: 163930-30-1
2-<4-(Benzyloxy)phenyl>ethyl iodide

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 209476-18-6
diethyl 2-acetamido-2-(4-(benzyloxy)phenethyl)malonate

Guidance literature:: 2-acetylaminomalonic acid diethyl ester; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.75h; Schlenk technique;

2-<4-(Benzyloxy)phenyl>ethyl iodide; In N,N-dimethyl-formamide; mineral oil; at 95 ℃; for 40h; Schlenk technique;
DOI:10.1039/c8cc05643a

Reference yield:

: 4397-53-9
p-benzyloxybenzaldehyde

: 209476-18-6
diethyl 2-acetamido-2-(4-(benzyloxy)phenethyl)malonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: methyl-triphenylphosphonium iodide; sodium hydride / tetrahydrofuran / 20 °C

2.1: borane-THF / 0 - 20 °C

2.2: 0 - 20 °C

3.1: iodine; triphenylphosphine; 1H-imidazole / dichloromethane / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 20 °C / Schlenk technique

4.2: 40 h / 95 °C / Schlenk technique

With 1H-imidazole; borane-THF; iodine; methyl-triphenylphosphonium iodide; sodium hydride; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c8cc05643a