2-(acetylamino)-2-[(acetyloxy)methyl]-4-(4-hydroxyphenyl)butyl acetate

Base Information

• Chemical Name: 2-(acetylamino)-2-[(acetyloxy)methyl]-4-(4-hydroxyphenyl)butyl acetate
• CAS No.: 162360-77-2
• Molecular Formula: C₁₇H₂₃NO₆
• Molecular Weight: 337.373
• Mol file: 162360-77-2.mol

Synonyms:2-(acetylamino)-2-[(acetyloxy)methyl]-4-(4-hydroxyphenyl)butyl acetate

Chemical Property of 2-(acetylamino)-2-[(acetyloxy)methyl]-4-(4-hydroxyphenyl)butyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(acetylamino)-2-[(acetyloxy)methyl]-4-(4-hydroxyphenyl)butyl acetate

There total 10 articles about 2-(acetylamino)-2-[(acetyloxy)methyl]-4-(4-hydroxyphenyl)butyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-(acetylamino)-2-[(acetyloxy)methyl]-4-(4-{[1-(tert-butyl)-1,1-dimethylsilyl]oxy}phenyl)butyl acetate (1070895-16-7) → 2-(acetylamino)-2-[(acetyloxy)methyl]-4-(4-hydroxyphenyl)butyl acetate (162360-77-2)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; diethyl ether; at 20 ℃; for 0.333333h;

DOI:10.1016/j.bmc.2008.07.003

Reference yield: 92.0%

2-acetamido-2-(4-(benzyloxy)phenethyl)propane-1,3-diyl diacetate (162360-75-0) → 2-(acetylamino)-2-[(acetyloxy)methyl]-4-(4-hydroxyphenyl)butyl acetate (162360-77-2)

Guidance literature:

With palladium on activated carbon; hydrogen; In ethanol; at 20 ℃; for 0.75h;

DOI:10.1039/c8cc05643a

Reference yield:

N-[3-(4-benzyloxy-phenyl)-1,1-bis-hydroxymethyl-propyl]-acetamide (1383437-37-3) → 2-(acetylamino)-2-[(acetyloxy)methyl]-4-(4-hydroxyphenyl)butyl acetate (162360-77-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; dmap / tetrahydrofuran / 72 h / 20 °C

2: palladium on activated carbon; hydrogen / ethanol / 0.75 h / 20 °C

With dmap; palladium on activated carbon; hydrogen; triethylamine; In tetrahydrofuran; ethanol;

DOI:10.1039/c8cc05643a

upstream raw materials:

2-(acetylamino)-2-[(acetyloxy)methyl]-4-(4-{[1-(tert-butyl)-1,1-dimethylsilyl]oxy}phenyl)butyl acetate

N-[3-(4-benzyloxy-phenyl)-1,1-bis-hydroxymethyl-propyl]-acetamide

p-benzyloxybenzaldehyde

2-<4-(Benzyloxy)phenyl>ethyl iodide

Downstream raw materials:

2-(acetylamino)-2-[(acetyloxy)methyl]-4-{4-[(trifluoromethanesulfonyl)oxy]phenyl}butyl acetate

2-acetamido-2-(4-(heptyloxy)phenethyl)propane-1,3-diyl diacetate

2-acetamido-2-(4-(pentanetyloxy)phenethyl)propane-1,3-diyl diacetate

2-amino-2-(4-(pentanetyloxy)phenethyl)propane-1,3-diol hydrochloride