N-{3-[(2R,6R)-6-(2,2-Diethoxy-ethyl)-2-((R)-1-methoxymethoxy-propyl)-3,6-dihydro-2H-pyridin-1-yl]-3-oxo-propyl}-4-methyl-benzenesulfonamide

Base Information

Chemical Name:N-{3-[(2R,6R)-6-(2,2-Diethoxy-ethyl)-2-((R)-1-methoxymethoxy-propyl)-3,6-dihydro-2H-pyridin-1-yl]-3-oxo-propyl}-4-methyl-benzenesulfonamide
CAS No.:94607-97-3
Molecular Formula:C₂₆H₄₂N₂O₇S
Molecular Weight:526.695
Hs Code.:

Synonyms:N-{3-[(2R,6R)-6-(2,2-Diethoxy-ethyl)-2-((R)-1-methoxymethoxy-propyl)-3,6-dihydro-2H-pyridin-1-yl]-3-oxo-propyl}-4-methyl-benzenesulfonamide

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Chemical Property of N-{3-[(2R,6R)-6-(2,2-Diethoxy-ethyl)-2-((R)-1-methoxymethoxy-propyl)-3,6-dihydro-2H-pyridin-1-yl]-3-oxo-propyl}-4-methyl-benzenesulfonamide

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Technology Process of N-{3-[(2R,6R)-6-(2,2-Diethoxy-ethyl)-2-((R)-1-methoxymethoxy-propyl)-3,6-dihydro-2H-pyridin-1-yl]-3-oxo-propyl}-4-methyl-benzenesulfonamide

There total 10 articles about N-{3-[(2R,6R)-6-(2,2-Diethoxy-ethyl)-2-((R)-1-methoxymethoxy-propyl)-3,6-dihydro-2H-pyridin-1-yl]-3-oxo-propyl}-4-methyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79477-05-7
(2R,3S,6S)-6-(2,2-Diethoxy-ethyl)-3-hydroxy-2-vinyl-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

: 94607-97-3
N-{3-[(2R,6R)-6-(2,2-Diethoxy-ethyl)-2-((R)-1-methoxymethoxy-propyl)-3,6-dihydro-2H-pyridin-1-yl]-3-oxo-propyl}-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

2: 88 percent / diisopropylethylamine / CH₂Cl₂ / 8 h / Heating

3: 100 percent / H₂O, K₂CO₃ / methanol / 2 h / Ambient temperature

4: 1.) 1,1'-thiocarbonyldiimidazole, 2.) Bu₃SnH, AIBN / 1.)ClCH₂CH₂Cl, r.t., 22 h, 2.) benzene, reflux, 10 h

5: Na / NH₃; tetrahydrofuran / 0.08 h / -70 °C

6: K₂CO₃ / toluene; benzene; H₂O / 1.)0 degC, 10 min., 2.) 10 degC, 1 h

With 2,2'-azobis(isobutyronitrile); water; tri-n-butyl-tin hydride; sodium; potassium carbonate; N-ethyl-N,N-diisopropylamine; 1,1'-Thiocarbonyldiimidazole; In tetrahydrofuran; methanol; dichloromethane; ammonia; water; toluene; benzene;

Reference yield:

: 94607-95-1
(2R,3R,6R)-6-(2,2-Diethoxy-ethyl)-3-hydroxy-2-((R)-1-methoxymethoxy-propyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

: 94607-97-3
N-{3-[(2R,6R)-6-(2,2-Diethoxy-ethyl)-2-((R)-1-methoxymethoxy-propyl)-3,6-dihydro-2H-pyridin-1-yl]-3-oxo-propyl}-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 1,1'-thiocarbonyldiimidazole, 2.) Bu₃SnH, AIBN / 1.)ClCH₂CH₂Cl, r.t., 22 h, 2.) benzene, reflux, 10 h

2: Na / NH₃; tetrahydrofuran / 0.08 h / -70 °C

3: K₂CO₃ / toluene; benzene; H₂O / 1.)0 degC, 10 min., 2.) 10 degC, 1 h

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium; potassium carbonate; 1,1'-Thiocarbonyldiimidazole; In tetrahydrofuran; ammonia; water; toluene; benzene;

Reference yield:

: 94607-94-0
(2R,3S,6S)-3-Benzoyloxy-6-(2,2-diethoxy-ethyl)-2-((S)-1-hydroxy-propyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

: 94607-97-3
N-{3-[(2R,6R)-6-(2,2-Diethoxy-ethyl)-2-((R)-1-methoxymethoxy-propyl)-3,6-dihydro-2H-pyridin-1-yl]-3-oxo-propyl}-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / diisopropylethylamine / CH₂Cl₂ / 8 h / Heating

2: 100 percent / H₂O, K₂CO₃ / methanol / 2 h / Ambient temperature

3: 1.) 1,1'-thiocarbonyldiimidazole, 2.) Bu₃SnH, AIBN / 1.)ClCH₂CH₂Cl, r.t., 22 h, 2.) benzene, reflux, 10 h

4: Na / NH₃; tetrahydrofuran / 0.08 h / -70 °C

5: K₂CO₃ / toluene; benzene; H₂O / 1.)0 degC, 10 min., 2.) 10 degC, 1 h

With 2,2'-azobis(isobutyronitrile); water; tri-n-butyl-tin hydride; sodium; potassium carbonate; N-ethyl-N,N-diisopropylamine; 1,1'-Thiocarbonyldiimidazole; In tetrahydrofuran; methanol; dichloromethane; ammonia; water; toluene; benzene;