N-(3-{(R)-2-[3-(5-amino-indol-1-yl)-1,1-dimethyl-propylamino]-1-hydroxy-ethyl}-phenyl)-benzenesulphonamide

Base Information

Chemical Name:N-(3-{(R)-2-[3-(5-amino-indol-1-yl)-1,1-dimethyl-propylamino]-1-hydroxy-ethyl}-phenyl)-benzenesulphonamide
CAS No.:936002-90-3
Molecular Formula:C₂₇H₃₂N₄O₃S
Molecular Weight:492.642
Hs Code.:

Synonyms:N-(3-{(R)-2-[3-(5-amino-indol-1-yl)-1,1-dimethyl-propylamino]-1-hydroxy-ethyl}-phenyl)-benzenesulphonamide

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Chemical Property of N-(3-{(R)-2-[3-(5-amino-indol-1-yl)-1,1-dimethyl-propylamino]-1-hydroxy-ethyl}-phenyl)-benzenesulphonamide

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Technology Process of N-(3-{(R)-2-[3-(5-amino-indol-1-yl)-1,1-dimethyl-propylamino]-1-hydroxy-ethyl}-phenyl)-benzenesulphonamide

There total 2 articles about N-(3-{(R)-2-[3-(5-amino-indol-1-yl)-1,1-dimethyl-propylamino]-1-hydroxy-ethyl}-phenyl)-benzenesulphonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 936002-81-2
N-(3-{(R)-2-[1,1-dimethyl-3-(5-nitroindol-1-yl)propylamino]-1-hydroxyethyl}phenyl)benzenesulphonamide

: 936002-90-3
N-(3-{(R)-2-[3-(5-amino-indol-1-yl)-1,1-dimethyl-propylamino]-1-hydroxy-ethyl}-phenyl)-benzenesulphonamide

Guidance literature:: With hydrogen; nickel; In methanol; ethyl acetate; at 20 ℃; for 7h; under 2250.23 Torr; Product distribution / selectivity;

Reference yield:

: N-(3-{(R)-2-[3-(5-aminoindol-1-yl)-1,1-dimethylpropylamino]-1-hydroxyethyl}phenyl)benzenesulphonamide di-hydrotrifluoroacetate

: 936002-90-3
N-(3-{(R)-2-[3-(5-amino-indol-1-yl)-1,1-dimethyl-propylamino]-1-hydroxy-ethyl}-phenyl)-benzenesulphonamide

Guidance literature:: With sodium carbonate; In chloroform; water; for 0.166667h; Product distribution / selectivity;

Reference yield: 71.0%

: 64-18-6
formic acid

: 936002-90-3
N-(3-{(R)-2-[3-(5-amino-indol-1-yl)-1,1-dimethyl-propylamino]-1-hydroxy-ethyl}-phenyl)-benzenesulphonamide

: 3160-59-6
N-Cbz-L-Isoleucine

: 936004-33-0
benzyl [(1S,2S)-1-(1-{3-[(R)-2-[3-(phenylsulphonylamino)phenyl]-2-hydroxyethylamino]-3-methylbutyl}-1H-indol-5-ylcarbamoyl)-2-methylbutyl]carbamate hydroformate

Guidance literature:: N-(3-{(R)-2-[3-(5-amino-indol-1-yl)-1,1-dimethyl-propylamino]-1-hydroxy-ethyl}-phenyl)-benzenesulphonamide; N-Cbz-L-Isoleucine; With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 2h;

formic acid; In water; acetonitrile;