C₂HF₃O₂*C₁₂H₁₄FNO₄

Base Information

• Chemical Name: C₂HF₃O₂*C₁₂H₁₄FNO₄
• CAS No.: 1042702-57-7
• Molecular Formula: C₂HF₃O₂*C₁₂H₁₄FNO₄
• Molecular Weight: 369.27
• Mol file: 1042702-57-7.mol

Synonyms:C₂HF₃O₂*C₁₂H₁₄FNO₄

Chemical Property of C₂HF₃O₂*C₁₂H₁₄FNO₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of C₂HF₃O₂*C₁₂H₁₄FNO₄

There total 4 articles about C₂HF₃O₂*C₁₂H₁₄FNO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-fluorophenol (372-20-3) → C2HF3O2*C12H14FNO4 (1042702-57-7)

Guidance literature:

Multi-step reaction with 7 steps

1: bromine; trifluoroacetic acid / 20 °C

2: potassium carbonate / acetonitrile / 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 100 °C

4: phenyltrimethylammonium tribromide / methanol; dichloromethane / 20 °C

5: potassium carbonate / acetonitrile / 20 °C

6: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 °C

7: 24 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; bromine; phenyltrimethylammonium tribromide; potassium carbonate; trifluoroacetic acid; In methanol; dichloromethane; ethyl acetate; toluene; acetonitrile; 3: Stille coupling;

DOI:10.1139/V10-143

Reference yield:

2-fluoro-4-benzyloxyacetophenone (119776-15-7) → C2HF3O2*C12H14FNO4 (1042702-57-7)

Guidance literature:

Multi-step reaction with 4 steps

1: phenyltrimethylammonium tribromide / methanol; dichloromethane / 20 °C

2: potassium carbonate / acetonitrile / 20 °C

3: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 °C

4: 24 h / 20 °C

With palladium 10% on activated carbon; hydrogen; phenyltrimethylammonium tribromide; potassium carbonate; In methanol; dichloromethane; ethyl acetate; acetonitrile;

DOI:10.1139/V10-143

Reference yield:

4-bromo-3-fluorophenol (121219-03-2) → C2HF3O2*C12H14FNO4 (1042702-57-7)

Guidance literature:

Multi-step reaction with 6 steps

1: potassium carbonate / acetonitrile / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 100 °C

3: phenyltrimethylammonium tribromide / methanol; dichloromethane / 20 °C

4: potassium carbonate / acetonitrile / 20 °C

5: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 °C

6: 24 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; phenyltrimethylammonium tribromide; potassium carbonate; In methanol; dichloromethane; ethyl acetate; toluene; acetonitrile; 2: Stille coupling;

DOI:10.1139/V10-143

upstream raw materials:

2-fluoro-4-benzyloxyacetophenone

trifluoroacetic acid

3-fluorophenol

4-bromo-3-fluorophenol

Downstream raw materials:

(2-fluoro-4-hydroxylphenyl)acetic acid