4-chloro-7-fluoro-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-c]pyridine

Base Information

Chemical Name:4-chloro-7-fluoro-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-c]pyridine
CAS No.:405231-08-5
Molecular Formula:C₃₂H₂₃ClFN₃O₇
Molecular Weight:616.002
Hs Code.:

Synonyms:4-chloro-7-fluoro-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-c]pyridine

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Chemical Property of 4-chloro-7-fluoro-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-c]pyridine

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Technology Process of 4-chloro-7-fluoro-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-c]pyridine

There total 10 articles about 4-chloro-7-fluoro-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 6974-32-9
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

: 405230-97-9
4-chloro-7-fluoro-1H-imidazo[4,5-c]pyridine

: 405231-08-5
4-chloro-7-fluoro-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-c]pyridine

Guidance literature:: 4-chloro-7-fluoro-1H-imidazo[4,5-c]pyridine; With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane; for 2h; Heating;

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose; With trimethylsilyl trifluoromethanesulfonate; In 1,2-dichloro-ethane; at 20 ℃;
DOI:10.1081/NCN-100108327

Reference yield: 61.0%

: 405231-08-5
4-chloro-7-fluoro-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-c]pyridine

Guidance literature:

Reference yield:

: 31301-51-6
2-chloro-5-fluoropyridine

: 405231-08-5
4-chloro-7-fluoro-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-c]pyridine

Guidance literature:: Multi-step reaction with 8 steps

1.1: 3.6 g / TFA; aq. H₂O₂ / 20 h / 70 - 75 °C

2.1: 59 percent / conc. H₂SO₄; KNO₃ / 2 h / 120 °C

3.1: 91 percent / H₂ / Raney Ni / ethanol / 3 h / 2068.59 Torr

4.1: 83 percent / conc. H₂SO₄; KNO₃ / 0 - 20 °C

5.1: 90 percent / conc. H₂SO₄ / 20 °C

6.1: 94 percent / H₂ / Raney Ni / ethanol

7.1: hexamethyldisilazane; (NH₄)2SO₄ / 2 h / Heating

7.2: 61 percent / TMSOTf / 1,2-dichloro-ethane / 20 °C

With ammonium sulfate; sulfuric acid; hydrogen; dihydrogen peroxide; potassium nitrate; 1,1,1,3,3,3-hexamethyl-disilazane; trifluoroacetic acid; nickel; In ethanol;
DOI:10.1081/NCN-100108327