Pyridine, 2-chloro-5-fluoro-, 1-oxide (9CI)

Base Information

• Chemical Name: Pyridine, 2-chloro-5-fluoro-, 1-oxide (9CI)
• CAS No.: 405230-79-7
• Molecular Formula: C5H3 Cl F N O
• Molecular Weight: 147.5348232
• Hs Code.: 2933399990
• Mol file: 405230-79-7.mol

Synonyms:Pyridine, 2-chloro-5-fluoro-, 1-oxide (9CI)

Chemical Property of Pyridine, 2-chloro-5-fluoro-, 1-oxide (9CI)

Chemical Property:

• Melting Point: 98-100℃
• Boiling Point: 311.3±22.0 °C(Predicted)
• PKA: -1.34±0.10(Predicted)
• PSA: 25.46000
• Density: 1.41±0.1 g/cm3(Predicted)
• LogP: 1.90760
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-5-fluoropyridine-N-oxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyridine, 2-chloro-5-fluoro-, 1-oxide (9CI)

There total 1 articles about Pyridine, 2-chloro-5-fluoro-, 1-oxide (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-chloro-5-fluoropyridine (31301-51-6) → 2-chloro-5-fluoropyridine-1-oxide (405230-79-7)

Guidance literature:

With dihydrogen peroxide; trifluoroacetic acid; at 70 ℃; for 16h; Inert atmosphere;

Reference yield: 64.9%

2-chloro-5-fluoropyridine-1-oxide (405230-79-7) → 2-chloro-5-fluoro-4-nitropyridine-1-oxide (405230-80-0)

Guidance literature:

With sulfuric acid; potassium nitrate; at 110 ℃; for 16h; Inert atmosphere;

Reference yield:

2-chloro-5-fluoropyridine-1-oxide (405230-79-7) → 4-chloro-7-fluoro-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-c]pyridine (405231-08-5)

Guidance literature:

Multi-step reaction with 7 steps

1.1: 59 percent / conc. H₂SO₄; KNO₃ / 2 h / 120 °C

2.1: 91 percent / H₂ / Raney Ni / ethanol / 3 h / 2068.59 Torr

3.1: 83 percent / conc. H₂SO₄; KNO₃ / 0 - 20 °C

4.1: 90 percent / conc. H₂SO₄ / 20 °C

5.1: 94 percent / H₂ / Raney Ni / ethanol

6.1: hexamethyldisilazane; (NH₄)2SO₄ / 2 h / Heating

6.2: 61 percent / TMSOTf / 1,2-dichloro-ethane / 20 °C

With ammonium sulfate; sulfuric acid; hydrogen; potassium nitrate; 1,1,1,3,3,3-hexamethyl-disilazane; nickel; In ethanol;

DOI:10.1081/NCN-100108327

upstream raw materials:

2-chloro-5-fluoropyridine

Downstream raw materials:

2-chloro-5-fluoro-4-nitropyridine-1-oxide

3-deaza-3-fluoro-adenosine

4-amino-2-chloro-5-fluoropyridine

4-chloro-7-fluoro-1H-imidazo[4,5-c]pyridine

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