4-(5-((2-phenethyl-1,2,3,4-tetrahydroisoquinolin-4-yl)-methyl)thiophen-2-yl)benzaldehyde

Base Information

Chemical Name:4-(5-((2-phenethyl-1,2,3,4-tetrahydroisoquinolin-4-yl)-methyl)thiophen-2-yl)benzaldehyde
CAS No.:1370354-71-4
Molecular Formula:C₂₉H₂₇NOS
Molecular Weight:437.605
Hs Code.:

Synonyms:4-(5-((2-phenethyl-1,2,3,4-tetrahydroisoquinolin-4-yl)-methyl)thiophen-2-yl)benzaldehyde

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Chemical Property of 4-(5-((2-phenethyl-1,2,3,4-tetrahydroisoquinolin-4-yl)-methyl)thiophen-2-yl)benzaldehyde

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Technology Process of 4-(5-((2-phenethyl-1,2,3,4-tetrahydroisoquinolin-4-yl)-methyl)thiophen-2-yl)benzaldehyde

There total 3 articles about 4-(5-((2-phenethyl-1,2,3,4-tetrahydroisoquinolin-4-yl)-methyl)thiophen-2-yl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1370354-58-7
2-phenethyl-4-(thiophen-2-ylmethyl)-1,2,3,4-tetrahydroisoquinoline

: 1122-91-4
4-bromo-benzaldehyde

: 1370354-71-4
4-(5-((2-phenethyl-1,2,3,4-tetrahydroisoquinolin-4-yl)-methyl)thiophen-2-yl)benzaldehyde

Guidance literature:: With potassium acetate; palladium diacetate; In N,N-dimethyl acetamide; at 150 ℃; for 15h; regioselective reaction; Inert atmosphere;
DOI:10.1021/jo300237s

Reference yield:

: 54105-61-2
2-(2-phenylethyl)-1,2,3,4-tetrahydroisoquinoline

: 1370354-71-4
4-(5-((2-phenethyl-1,2,3,4-tetrahydroisoquinolin-4-yl)-methyl)thiophen-2-yl)benzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: [Ru(p-cymene)(k⁽²⁾-o-tBuPPBS)Cl]; (1S)-10-camphorsulfonic acid / toluene / 15 h / 150 °C / Inert atmosphere

1.2: 1 h / 150 °C / Inert atmosphere

2.1: potassium acetate; palladium diacetate / N,N-dimethyl acetamide / 15 h / 150 °C / Inert atmosphere

With [Ru(p-cymene)(k⁽²⁾-o-tBuPPBS)Cl]; (1S)-10-camphorsulfonic acid; potassium acetate; palladium diacetate; In N,N-dimethyl acetamide; toluene;
DOI:10.1021/jo300237s

Reference yield:

: 98-03-3
thiophene-2-carbaldehyde

: 1370354-71-4
4-(5-((2-phenethyl-1,2,3,4-tetrahydroisoquinolin-4-yl)-methyl)thiophen-2-yl)benzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: [Ru(p-cymene)(k⁽²⁾-o-tBuPPBS)Cl]; (1S)-10-camphorsulfonic acid / toluene / 15 h / 150 °C / Inert atmosphere

1.2: 1 h / 150 °C / Inert atmosphere

2.1: potassium acetate; palladium diacetate / N,N-dimethyl acetamide / 15 h / 150 °C / Inert atmosphere

With [Ru(p-cymene)(k⁽²⁾-o-tBuPPBS)Cl]; (1S)-10-camphorsulfonic acid; potassium acetate; palladium diacetate; In N,N-dimethyl acetamide; toluene;
DOI:10.1021/jo300237s