[2-(Hydroxy-phenyl-methyl)-3-methyl-3-trimethylsilanyl-cycloprop-1-enyl]-phenyl-methanol

Base Information

Chemical Name:[2-(Hydroxy-phenyl-methyl)-3-methyl-3-trimethylsilanyl-cycloprop-1-enyl]-phenyl-methanol
CAS No.:198643-14-0
Molecular Formula:C₂₁H₂₆O₂Si
Molecular Weight:338.522
Hs Code.:

Synonyms:[2-(Hydroxy-phenyl-methyl)-3-methyl-3-trimethylsilanyl-cycloprop-1-enyl]-phenyl-methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [2-(Hydroxy-phenyl-methyl)-3-methyl-3-trimethylsilanyl-cycloprop-1-enyl]-phenyl-methanol

Chemical Property:

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Technology Process of [2-(Hydroxy-phenyl-methyl)-3-methyl-3-trimethylsilanyl-cycloprop-1-enyl]-phenyl-methanol

There total 7 articles about [2-(Hydroxy-phenyl-methyl)-3-methyl-3-trimethylsilanyl-cycloprop-1-enyl]-phenyl-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 100-52-7
benzaldehyde

: 198643-13-9
(3-Methyl-3-trimethylsilanyl-cycloprop-1-enyl)-phenyl-methanol

: 198643-14-0
[2-(Hydroxy-phenyl-methyl)-3-methyl-3-trimethylsilanyl-cycloprop-1-enyl]-phenyl-methanol

Guidance literature:: With methyllithium;
DOI:10.1016/S0040-4039(97)01801-7

Reference yield:

: 52685-47-9
(Z)-3-(trimethylsilyl)but-2-en-1-ol

: 198643-14-0
[2-(Hydroxy-phenyl-methyl)-3-methyl-3-trimethylsilanyl-cycloprop-1-enyl]-phenyl-methanol

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / oxalyl chloride, N,N-dimethylformamide / hexane

2: 20 percent / sodium amide / tetrahydrofuran / 45 °C

3: 78 percent / methyllithium / -78 °C

4: 61 percent / methyllithium

With oxalyl dichloride; methyllithium; sodium amide; N,N-dimethyl-formamide; In tetrahydrofuran; hexane;
DOI:10.1016/S0040-4039(97)01801-7

Reference yield:

: 13411-48-8
1-(trimethylsilyl)ethanone

: 198643-14-0
[2-(Hydroxy-phenyl-methyl)-3-methyl-3-trimethylsilanyl-cycloprop-1-enyl]-phenyl-methanol

Guidance literature:: Multi-step reaction with 6 steps

1: 71 percent / LDA, HMPA / tetrahydrofuran

2: 83 percent / LiAlH₄ / diethyl ether

3: 76 percent / oxalyl chloride, N,N-dimethylformamide / hexane

4: 20 percent / sodium amide / tetrahydrofuran / 45 °C

5: 78 percent / methyllithium / -78 °C

6: 61 percent / methyllithium

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium aluminium tetrahydride; oxalyl dichloride; methyllithium; sodium amide; N,N-dimethyl-formamide; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1016/S0040-4039(97)01801-7