1-[[2-(2,3-dichlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(2-hydroxyethoxymethyl)phenyl]urea

Base Information

Chemical Name:1-[[2-(2,3-dichlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(2-hydroxyethoxymethyl)phenyl]urea
CAS No.:1402581-54-7
Molecular Formula:C₂₁H₁₈Cl₂F₄N₄O₃
Molecular Weight:521.299
Hs Code.:

Synonyms:1-[[2-(2,3-dichlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(2-hydroxyethoxymethyl)phenyl]urea

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Chemical Property of 1-[[2-(2,3-dichlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(2-hydroxyethoxymethyl)phenyl]urea

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Technology Process of 1-[[2-(2,3-dichlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(2-hydroxyethoxymethyl)phenyl]urea

There total 11 articles about 1-[[2-(2,3-dichlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(2-hydroxyethoxymethyl)phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1402585-37-8
(1-(2,3-dichlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine hydrochloride

: 2-(4-(benzoyloxyamino)-2-fluorobenzyloxy)ethanol

: 1402581-54-7
1-[[2-(2,3-dichlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(2-hydroxyethoxymethyl)phenyl]urea

Guidance literature:: With triethylamine; In acetonitrile; for 16h; Reflux;

Reference yield:

: 392-09-6
2-fluoro-4-nitro-benzoic acid methyl ester

: 1402581-54-7
1-[[2-(2,3-dichlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(2-hydroxyethoxymethyl)phenyl]urea

Guidance literature:: Multi-step reaction with 6 steps

1: methanol; sodium tetrahydroborate / 4 h / 23 °C

2: N-Bromosuccinimide; triphenylphosphine / dichloromethane / 2 h / 0 - 23 °C

3: sodium hydride / 16 h / 23 °C

4: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 16 h

5: pyridine / acetone / 1 h / 0 - 23 °C

6: triethylamine / acetonitrile / 16 h / Reflux

With pyridine; methanol; sodium tetrahydroborate; N-Bromosuccinimide; palladium 10% on activated carbon; hydrogen; sodium hydride; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; acetone; acetonitrile;

Reference yield:

: 660432-43-9
(2-fluoro-4-nitrophenyl)methanol

: 1402581-54-7
1-[[2-(2,3-dichlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(2-hydroxyethoxymethyl)phenyl]urea

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide; triphenylphosphine / dichloromethane / 2 h / 0 - 23 °C

2: sodium hydride / 16 h / 23 °C

3: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 16 h

4: pyridine / acetone / 1 h / 0 - 23 °C

5: triethylamine / acetonitrile / 16 h / Reflux

With pyridine; N-Bromosuccinimide; palladium 10% on activated carbon; hydrogen; sodium hydride; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; acetone; acetonitrile;