Phosphoric acid (S)-2-amino-3-(4-hydroxy-phenyl)-propyl ester (3aR,4R,6R,6aR)-6-(6-amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

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Chemical Name:Phosphoric acid (S)-2-amino-3-(4-hydroxy-phenyl)-propyl ester (3aR,4R,6R,6aR)-6-(6-amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester
CAS No.:256643-00-2
Molecular Formula:C₂₂H₂₉N₆O₈P
Molecular Weight:536.481
Hs Code.:

Phosphoric acid (S)-2-amino-3-(4-hydroxy-phenyl)-propyl ester (3aR,4R,6R,6aR)-6-(6-amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

Synonyms:Phosphoric acid (S)-2-amino-3-(4-hydroxy-phenyl)-propyl ester (3aR,4R,6R,6aR)-6-(6-amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

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Chemical Property of Phosphoric acid (S)-2-amino-3-(4-hydroxy-phenyl)-propyl ester (3aR,4R,6R,6aR)-6-(6-amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

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Technology Process of Phosphoric acid (S)-2-amino-3-(4-hydroxy-phenyl)-propyl ester (3aR,4R,6R,6aR)-6-(6-amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

There total 5 articles about Phosphoric acid (S)-2-amino-3-(4-hydroxy-phenyl)-propyl ester (3aR,4R,6R,6aR)-6-(6-amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: [(S)-2-{[(3aR,4R,6R,6aR)-6-(6-Amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy]-hydroxy-phosphoryloxy}-1-(4-hydroxy-benzyl)-ethyl]-carbamic acid benzyl ester

: 256643-00-2
Phosphoric acid (S)-2-amino-3-(4-hydroxy-phenyl)-propyl ester (3aR,4R,6R,6aR)-6-(6-amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In 1,4-dioxane; water; acetic acid;
DOI:10.1016/S0968-0896(99)00192-3

Reference yield:

: 39947-04-1
N-6-benzoyl-2',3'-O-isopropylideneadenosine

: 256643-00-2
Phosphoric acid (S)-2-amino-3-(4-hydroxy-phenyl)-propyl ester (3aR,4R,6R,6aR)-6-(6-amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: iPr₂NEt / CH₂Cl₂ / 0.25 h / 20 °C

2: 1H-tetrazole / acetonitrile / 0.25 h / 20 °C

3: 0.723 g / I₂; 2,6-lutidine / H₂O; tetrahydrofuran / 0.25 h

4: 81 percent / n-BuNH₂ / methanol / 24 h / 20 °C

5: 41 percent / H₂ / Pd/C / dioxane; H₂O; acetic acid

With 2,6-dimethylpyridine; 1H-tetrazole; hydrogen; iodine; N-butylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetic acid; acetonitrile; 1: Substitution / 2: Substitution / 3: Oxidation / 4: Hydrolysis / 5: Catalytic hydrogenation;
DOI:10.1016/S0968-0896(99)00192-3

Reference yield:

: 155264-06-5
Diisopropyl-phosphoramidous acid (3aR,4R,6R,6aR)-6-(6-benzoylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester methyl ester

: 256643-00-2
Phosphoric acid (S)-2-amino-3-(4-hydroxy-phenyl)-propyl ester (3aR,4R,6R,6aR)-6-(6-amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1H-tetrazole / acetonitrile / 0.25 h / 20 °C

2: 0.723 g / I₂; 2,6-lutidine / H₂O; tetrahydrofuran / 0.25 h

3: 81 percent / n-BuNH₂ / methanol / 24 h / 20 °C

4: 41 percent / H₂ / Pd/C / dioxane; H₂O; acetic acid

With 2,6-dimethylpyridine; 1H-tetrazole; hydrogen; iodine; N-butylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; water; acetic acid; acetonitrile; 1: Substitution / 2: Oxidation / 3: Hydrolysis / 4: Catalytic hydrogenation;
DOI:10.1016/S0968-0896(99)00192-3