Diisopropyl-phosphoramidous acid (3aR,4R,6R,6aR)-6-(6-benzoylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester methyl ester

Base Information

Chemical Name:Diisopropyl-phosphoramidous acid (3aR,4R,6R,6aR)-6-(6-benzoylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester methyl ester
CAS No.:155264-06-5
Molecular Formula:C₂₇H₃₇N₆O₆P
Molecular Weight:572.601
Hs Code.:

Diisopropyl-phosphoramidous acid (3aR,4R,6R,6aR)-6-(6-benzoylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester methyl ester

Synonyms:Diisopropyl-phosphoramidous acid (3aR,4R,6R,6aR)-6-(6-benzoylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester methyl ester

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Chemical Property of Diisopropyl-phosphoramidous acid (3aR,4R,6R,6aR)-6-(6-benzoylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester methyl ester

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Technology Process of Diisopropyl-phosphoramidous acid (3aR,4R,6R,6aR)-6-(6-benzoylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester methyl ester

There total 1 articles about Diisopropyl-phosphoramidous acid (3aR,4R,6R,6aR)-6-(6-benzoylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 86030-43-5
N,N-diisopropylmethylphosphonamidic chloride

: 39947-04-1
N-6-benzoyl-2',3'-O-isopropylideneadenosine

: 155264-06-5
Diisopropyl-phosphoramidous acid (3aR,4R,6R,6aR)-6-(6-benzoylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester methyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.2h; Ambient temperature;
DOI:10.1006/bioo.1998.1082

Reference yield: 78.0%

: 110559-89-2
benzyl 4-<(benzyloxycarbonyl)amino>-5-hydroxypentanoate

: 155264-06-5
Diisopropyl-phosphoramidous acid (3aR,4R,6R,6aR)-6-(6-benzoylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester methyl ester

: (S)-5-{[(3aR,4R,6R,6aR)-6-(6-Benzoylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy]-methoxy-phosphanyloxy}-4-benzyloxycarbonylamino-pentanoic acid benzyl ester

Guidance literature:: With 1H-tetrazole; In acetonitrile; for 5h; Ambient temperature;
DOI:10.1006/bioo.1998.1082

Reference yield:

: 155264-06-5
Diisopropyl-phosphoramidous acid (3aR,4R,6R,6aR)-6-(6-benzoylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester methyl ester

: C₂₂H₂₆N₆O₁₀P^(1-)*Na⁽¹⁺⁾

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / tetrazole / acetonitrile / 5 h / Ambient temperature

2: aq. I₂ / pyridine; tetrahydrofuran

3: 93 percent / 90 percent aq. trifluoroacetic acid / 0.17 h / Ambient temperature

4: 79 percent / NaI / butan-2-one / 4 h / Heating

5: 100 percent / H₂ / 10 percent Pd/C / H₂O / 4 h / 2068.59 Torr

With 1H-tetrazole; hydrogen; iodine; trifluoroacetic acid; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; pyridine; water; acetonitrile; butanone;
DOI:10.1006/bioo.1998.1082