2-[N-[2-[N-benzoyl-N-(2,4-dimethoxybenzyl)]aminoacetyl]-N-[4-hydroxy-2-methoxybenzyl]]amino-N-(4-methoxyphenyl)acetamide

Base Information

Chemical Name:2-[N-[2-[N-benzoyl-N-(2,4-dimethoxybenzyl)]aminoacetyl]-N-[4-hydroxy-2-methoxybenzyl]]amino-N-(4-methoxyphenyl)acetamide
CAS No.:1341219-89-3
Molecular Formula:C₃₅H₃₇N₃O₈
Molecular Weight:627.694
Hs Code.:

Synonyms:2-[N-[2-[N-benzoyl-N-(2,4-dimethoxybenzyl)]aminoacetyl]-N-[4-hydroxy-2-methoxybenzyl]]amino-N-(4-methoxyphenyl)acetamide

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Chemical Property of 2-[N-[2-[N-benzoyl-N-(2,4-dimethoxybenzyl)]aminoacetyl]-N-[4-hydroxy-2-methoxybenzyl]]amino-N-(4-methoxyphenyl)acetamide

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Technology Process of 2-[N-[2-[N-benzoyl-N-(2,4-dimethoxybenzyl)]aminoacetyl]-N-[4-hydroxy-2-methoxybenzyl]]amino-N-(4-methoxyphenyl)acetamide

There total 7 articles about 2-[N-[2-[N-benzoyl-N-(2,4-dimethoxybenzyl)]aminoacetyl]-N-[4-hydroxy-2-methoxybenzyl]]amino-N-(4-methoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1341219-59-7
2-[N-[2-[N-benzoyl-N-(2,4-dimethoxybenzyl)]aminoacetyl]-N-[4-tert-butyldimethylsiloxy-2-methoxybenzyl]]amino-N-(4-methoxyphenyl)acetamide

: 1341219-89-3
2-[N-[2-[N-benzoyl-N-(2,4-dimethoxybenzyl)]aminoacetyl]-N-[4-hydroxy-2-methoxybenzyl]]amino-N-(4-methoxyphenyl)acetamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.166667h; Microwave irradiation;
DOI:10.1021/jo201495w

Reference yield:

: 912296-79-8
N-benzoyl-N-(2,4-dimethoxybenzyl)glycine benzyl ester

: 1341219-89-3
2-[N-[2-[N-benzoyl-N-(2,4-dimethoxybenzyl)]aminoacetyl]-N-[4-hydroxy-2-methoxybenzyl]]amino-N-(4-methoxyphenyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 20 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h / 20 °C / Microwave irradiation

With dmap; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo201495w

Reference yield:

: 129742-36-5
(4-((tert-butyldimethylsilyl)oxy)-2-methoxybenzaldehyde)

: 1341219-89-3
2-[N-[2-[N-benzoyl-N-(2,4-dimethoxybenzyl)]aminoacetyl]-N-[4-hydroxy-2-methoxybenzyl]]amino-N-(4-methoxyphenyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane / 0.33 h / 20 °C

2: sodium tris(acetoxy)borohydride / dichloromethane / 0.5 h / 0 - 20 °C

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h / 20 °C / Microwave irradiation

With dmap; tetrabutyl ammonium fluoride; sodium tris(acetoxy)borohydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo201495w