N-(8-((5-chloro-2-methoxyphenyl)amino)-5,6-dihydro-4H-cyclohepta[1,2-d:3,4-d′]bis(thiazole)-2-yl)pivalamide

Base Information

• Chemical Name: N-(8-((5-chloro-2-methoxyphenyl)amino)-5,6-dihydro-4H-cyclohepta[1,2-d:3,4-d′]bis(thiazole)-2-yl)pivalamide
• CAS No.: 1067637-97-1
• Molecular Formula: C₂₁H₂₃ClN₄O₂S₂
• Molecular Weight: 463.024
• Mol file: 1067637-97-1.mol

Synonyms:N-(8-((5-chloro-2-methoxyphenyl)amino)-5,6-dihydro-4H-cyclohepta[1,2-d:3,4-d′]bis(thiazole)-2-yl)pivalamide

Chemical Property of N-(8-((5-chloro-2-methoxyphenyl)amino)-5,6-dihydro-4H-cyclohepta[1,2-d:3,4-d′]bis(thiazole)-2-yl)pivalamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(8-((5-chloro-2-methoxyphenyl)amino)-5,6-dihydro-4H-cyclohepta[1,2-d:3,4-d′]bis(thiazole)-2-yl)pivalamide

There total 8 articles about N-(8-((5-chloro-2-methoxyphenyl)amino)-5,6-dihydro-4H-cyclohepta[1,2-d:3,4-d′]bis(thiazole)-2-yl)pivalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

N-8-(5-chloro-2-methoxyphenyl)-5,6-dihydro-4H-cyclohepta[1,2-d:3,4-d′]bis(thiazole)-2,8-diamine (1067637-96-0) + pivaloyl chloride (3282-30-2) → N-(8-((5-chloro-2-methoxyphenyl)amino)-5,6-dihydro-4H-cyclohepta[1,2-d:3,4-d′]bis(thiazole)-2-yl)pivalamide (1067637-97-1)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/jm800533c

Reference yield:

2-bromocycloheptane-1,3-dione (1017589-91-1) → N-(8-((5-chloro-2-methoxyphenyl)amino)-5,6-dihydro-4H-cyclohepta[1,2-d:3,4-d′]bis(thiazole)-2-yl)pivalamide (1067637-97-1)

Guidance literature:

Multi-step reaction with 4 steps

1: ethanol / 20 °C

2: bromine; acetic acid / 0.5 h / 20 °C

3: ethanol / Reflux

4: triethylamine / tetrahydrofuran / 60 °C / Inert atmosphere

With bromine; acetic acid; triethylamine; In tetrahydrofuran; ethanol;

DOI:10.1021/jm5007885

Reference yield:

cycloheptane-1,3-dione (1194-18-9) → N-(8-((5-chloro-2-methoxyphenyl)amino)-5,6-dihydro-4H-cyclohepta[1,2-d:3,4-d′]bis(thiazole)-2-yl)pivalamide (1067637-97-1)

Guidance literature:

Multi-step reaction with 5 steps

1: bromine / chloroform; water / 1 h / Cooling with ice

2: ethanol / 20 °C

3: bromine; acetic acid / 0.5 h / 20 °C

4: ethanol / Reflux

5: triethylamine / tetrahydrofuran / 60 °C / Inert atmosphere

With bromine; acetic acid; triethylamine; In tetrahydrofuran; ethanol; chloroform; water;

DOI:10.1021/jm5007885

upstream raw materials:

N-8-(5-chloro-2-methoxyphenyl)-5,6-dihydro-4H-cyclohepta[1,2-d:3,4-d′]bis(thiazole)-2,8-diamine

pivaloyl chloride

cycloheptane-1,3-dione

2-bromocycloheptane-1,3-dione