N-(3-{1-[1-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(1-oxypyridin-4-yl)ethyl]-1H-pyrazol-3-yl}phenyl)acetamide

Base Information

Chemical Name:N-(3-{1-[1-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(1-oxypyridin-4-yl)ethyl]-1H-pyrazol-3-yl}phenyl)acetamide
CAS No.:1367625-72-6
Molecular Formula:C₂₉H₂₈F₂N₄O₄
Molecular Weight:534.563
Hs Code.:

Synonyms:N-(3-{1-[1-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(1-oxypyridin-4-yl)ethyl]-1H-pyrazol-3-yl}phenyl)acetamide

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Chemical Property of N-(3-{1-[1-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(1-oxypyridin-4-yl)ethyl]-1H-pyrazol-3-yl}phenyl)acetamide

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Technology Process of N-(3-{1-[1-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(1-oxypyridin-4-yl)ethyl]-1H-pyrazol-3-yl}phenyl)acetamide

There total 7 articles about N-(3-{1-[1-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(1-oxypyridin-4-yl)ethyl]-1H-pyrazol-3-yl}phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1367625-75-9
N-(3-{1-[1-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(pyridin-4-yl)ethyl]-1H-pyrazol-3-yl}phenyl)acetamide

: 1367625-72-6
N-(3-{1-[1-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(1-oxypyridin-4-yl)ethyl]-1H-pyrazol-3-yl}phenyl)acetamide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1039/c2ob06495b

Reference yield:

: 54401-85-3
pyridin-4-yl-acetic acid ethyl ester

: 1367625-72-6
N-(3-{1-[1-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(1-oxypyridin-4-yl)ethyl]-1H-pyrazol-3-yl}phenyl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium acetate / acetic acid / 18 h / Reflux

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 - 20 °C

2.2: 6 h / -78 - 20 °C

3.1: lithium hydroxide / methanol; water / 20 °C

4.1: palladium 10% on activated carbon; hydrogen / ethanol / 5 h / 20 °C

5.1: triethylamine / dichloromethane / 6 h / 20 °C

6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 20 °C

With palladium 10% on activated carbon; ammonium acetate; hydrogen; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetic acid; 2.2: Michael condensation;
DOI:10.1039/c2ob06495b

Reference yield:

: 1367625-74-8
3-{1-[1-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(pyridin-4-yl)ethyl]-1H-pyrazol-3-yl}phenylamine

: 1367625-72-6
N-(3-{1-[1-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(1-oxypyridin-4-yl)ethyl]-1H-pyrazol-3-yl}phenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 6 h / 20 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 20 °C

With triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1039/c2ob06495b