3-{1-[1-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(pyridin-4-yl)ethyl]-1H-pyrazol-3-yl}phenylamine

Base Information

Chemical Name:3-{1-[1-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(pyridin-4-yl)ethyl]-1H-pyrazol-3-yl}phenylamine
CAS No.:1367625-74-8
Molecular Formula:C₂₇H₂₆F₂N₄O₂
Molecular Weight:476.526
Hs Code.:

Synonyms:3-{1-[1-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(pyridin-4-yl)ethyl]-1H-pyrazol-3-yl}phenylamine

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Chemical Property of 3-{1-[1-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(pyridin-4-yl)ethyl]-1H-pyrazol-3-yl}phenylamine

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Technology Process of 3-{1-[1-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(pyridin-4-yl)ethyl]-1H-pyrazol-3-yl}phenylamine

There total 4 articles about 3-{1-[1-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(pyridin-4-yl)ethyl]-1H-pyrazol-3-yl}phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 54401-85-3
pyridin-4-yl-acetic acid ethyl ester

: 1367625-74-8
3-{1-[1-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(pyridin-4-yl)ethyl]-1H-pyrazol-3-yl}phenylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium acetate / acetic acid / 18 h / Reflux

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 - 20 °C

2.2: 6 h / -78 - 20 °C

3.1: lithium hydroxide / methanol; water / 20 °C

4.1: palladium 10% on activated carbon; hydrogen / ethanol / 5 h / 20 °C

With palladium 10% on activated carbon; ammonium acetate; hydrogen; lithium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; ethanol; water; acetic acid; 2.2: Michael condensation;
DOI:10.1039/c2ob06495b

Reference yield:

: 151103-09-2
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

: 1367625-74-8
3-{1-[1-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(pyridin-4-yl)ethyl]-1H-pyrazol-3-yl}phenylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium acetate / acetic acid / 18 h / Reflux

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 - 20 °C

2.2: 6 h / -78 - 20 °C

3.1: lithium hydroxide / methanol; water / 20 °C

4.1: palladium 10% on activated carbon; hydrogen / ethanol / 5 h / 20 °C

With palladium 10% on activated carbon; ammonium acetate; hydrogen; lithium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; ethanol; water; acetic acid; 2.2: Michael condensation;
DOI:10.1039/c2ob06495b

Reference yield:

: 1041846-46-1
3-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(pyridin-4-yl)acrylic acid ethyl ester

: 1367625-74-8
3-{1-[1-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(pyridin-4-yl)ethyl]-1H-pyrazol-3-yl}phenylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 - 20 °C

1.2: 6 h / -78 - 20 °C

2.1: lithium hydroxide / methanol; water / 20 °C

3.1: palladium 10% on activated carbon; hydrogen / ethanol / 5 h / 20 °C

With palladium 10% on activated carbon; hydrogen; lithium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; ethanol; water; 1.2: Michael condensation;
DOI:10.1039/c2ob06495b