3-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(pyridin-4-yl)acrylic acid ethyl ester

Base Information

Chemical Name:3-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(pyridin-4-yl)acrylic acid ethyl ester
CAS No.:1041846-46-1
Molecular Formula:C₂₁H₂₁F₂NO₄
Molecular Weight:389.399
Hs Code.:

Synonyms:3-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(pyridin-4-yl)acrylic acid ethyl ester

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Chemical Property of 3-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(pyridin-4-yl)acrylic acid ethyl ester

Chemical Property:

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Technology Process of 3-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(pyridin-4-yl)acrylic acid ethyl ester

There total 1 articles about 3-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(pyridin-4-yl)acrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 54401-85-3
pyridin-4-yl-acetic acid ethyl ester

: 151103-09-2
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

: 1041846-46-1
3-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(pyridin-4-yl)acrylic acid ethyl ester

Guidance literature:: With ammonium acetate; In acetic acid; for 18h; Reflux;
DOI:10.1039/c2ob06495b

Reference yield:

: 1041846-46-1
3-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(pyridin-4-yl)acrylic acid ethyl ester

: 59843-77-5
1-(1H-pyrazol-3-yl)-3-nitrobenzene

: C₃₀H₂₈F₂N₄O₆

Guidance literature:: 1-(1H-pyrazol-3-yl)-3-nitrobenzene; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 20 ℃; for 0.5h;

3-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(pyridin-4-yl)acrylic acid ethyl ester; In tetrahydrofuran; at -78 - 20 ℃; for 6h;
DOI:10.1039/c2ob06495b

Reference yield:

: 1041846-46-1
3-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(pyridin-4-yl)acrylic acid ethyl ester

: 1367625-72-6
N-(3-{1-[1-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(1-oxypyridin-4-yl)ethyl]-1H-pyrazol-3-yl}phenyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 - 20 °C

1.2: 6 h / -78 - 20 °C

2.1: lithium hydroxide / methanol; water / 20 °C

3.1: palladium 10% on activated carbon; hydrogen / ethanol / 5 h / 20 °C

4.1: triethylamine / dichloromethane / 6 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; 1.2: Michael condensation;
DOI:10.1039/c2ob06495b