1-(3,5-di-tert-butyl-2-hydroxyphenyl)-2,2,2-trifluoroethanone

Base Information

• Chemical Name: 1-(3,5-di-tert-butyl-2-hydroxyphenyl)-2,2,2-trifluoroethanone
• CAS No.: 460048-35-5
• Molecular Formula: C₁₆H₂₁F₃O₂
• Molecular Weight: 302.337
• Mol file: 460048-35-5.mol

Synonyms:1-(3,5-di-tert-butyl-2-hydroxyphenyl)-2,2,2-trifluoroethanone

Chemical Property of 1-(3,5-di-tert-butyl-2-hydroxyphenyl)-2,2,2-trifluoroethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3,5-di-tert-butyl-2-hydroxyphenyl)-2,2,2-trifluoroethanone

There total 1 articles about 1-(3,5-di-tert-butyl-2-hydroxyphenyl)-2,2,2-trifluoroethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

ethyl trifluoroacetate, (383-63-1) + 2-bromo-4,6-di-tert-butylphenol (20834-61-1) → 1-(3,5-di-tert-butyl-2-hydroxyphenyl)-2,2,2-trifluoroethanone (460048-35-5)

Guidance literature:

With n-butyllithium; In diethyl ether; at -78 ℃;

DOI:10.1016/S0960-894X(03)00703-0

Reference yield: 73.0%

1-(3,5-di-tert-butyl-2-hydroxyphenyl)-2,2,2-trifluoroethanone (460048-35-5) → 1-(2,4-di-tert-buthylphenyl)-2,2,2-trifluoromethylethanone-1 (1234321-80-2)

Guidance literature:

With sodium tetrahydroborate; In methanol;

DOI:10.1016/j.jorganchem.2015.08.017

Reference yield:

1-(3,5-di-tert-butyl-2-hydroxyphenyl)-2,2,2-trifluoroethanone (460048-35-5) → (2E,4E,6E)-7-(3,5-Di-tert-butyl-2-ethoxy-phenyl)-8,8,8-trifluoro-3-methyl-octa-2,4,6-trienoic acid ethyl ester

Guidance literature:

Multi-step reaction with 5 steps

1: NaH / dimethylformamide

2: NaH / dimethylformamide / 0 - 20 °C

3: DIBAL / diethyl ether

4: TPAP; NMO / CH₂Cl₂

5: NaH / dimethylformamide / 0 - 20 °C

With N-methyl-2-indolinone; tetrapropylammonium perruthennate; sodium hydride; diisobutylaluminium hydride; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; 2: Horner-Emmons condensation / 5: Horner-Emmons condensation;

DOI:10.1016/S0960-894X(03)00703-0

upstream raw materials:

ethyl trifluoroacetate,

2-bromo-4,6-di-tert-butylphenol

Downstream raw materials:

1-(3,5-di-tert-butyl-2-ethoxy-phenyl)-2,2,2-trifluoro-ethanone

3-(3,5-di-tert-butyl-2-ethoxy-phenyl)-4,4,4-trifluoro-but-2-enal

3-(3,5-di-tert-butyl-2-ethoxy-phenyl)-4,4,4-trifluoro-but-2-en-1-ol

3-(3,5-di-tert-butyl-2-ethoxy-phenyl)-4,4,4-trifluoro-but-2-enoic acid methyl ester