N-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenyl)-2-hydroxyacetamide

Base Information

Chemical Name:N-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenyl)-2-hydroxyacetamide
CAS No.:1044870-86-1
Molecular Formula:C₂₀H₂₁N₃O₅
Molecular Weight:383.404
Hs Code.:

Synonyms:N-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenyl)-2-hydroxyacetamide

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Chemical Property of N-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenyl)-2-hydroxyacetamide

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Technology Process of N-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenyl)-2-hydroxyacetamide

There total 5 articles about N-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenyl)-2-hydroxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1044872-34-5
acetic acid [4-(5,7-dimethoxy-4-oxo-3,4-dihydro-quinazolin-2-yl)-2,6-dimethyl-phenylcarbamoyl]-methyl ester

: 1044870-86-1
N-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenyl)-2-hydroxyacetamide

Guidance literature:: acetic acid [4-(5,7-dimethoxy-4-oxo-3,4-dihydro-quinazolin-2-yl)-2,6-dimethyl-phenylcarbamoyl]-methyl ester; With potassium carbonate; In methanol; dichloromethane; water; at 20 ℃; for 17h;

With hydrogenchloride; In methanol; dichloromethane; water; pH=~ 8;

Reference yield:

: 21544-81-0
4,6-dimethoxyindoline-2,3-dione

: 1044870-86-1
N-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenyl)-2-hydroxyacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 70 °C

1.2: 3 h / 20 °C

1.3: 16 h / 20 °C

2.1: sodium hydrogensulfite; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 17 h / 150 °C / Inert atmosphere

3.1: potassium carbonate / water; dichloromethane; methanol / 17 h / 20 °C

With dihydrogen peroxide; potassium carbonate; toluene-4-sulfonic acid; sodium hydrogensulfite; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide; water;

Reference yield:

: 63920-73-0
2-amino-4,6-dimethoxybenzamide

: 1044870-86-1
N-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenyl)-2-hydroxyacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogensulfite; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 17 h / 150 °C / Inert atmosphere

2: potassium carbonate / water; dichloromethane; methanol / 17 h / 20 °C

With potassium carbonate; toluene-4-sulfonic acid; sodium hydrogensulfite; In methanol; dichloromethane; N,N-dimethyl acetamide; water;