N-Acetyl-leucyl-phenylalanyl trifluoromethyl ketone

Base Information

Chemical Name:N-Acetyl-leucyl-phenylalanyl trifluoromethyl ketone
CAS No.:113215-69-3
Molecular Formula:C₁₈H₂₃F₃N₂O₃
Molecular Weight:372.387
Hs Code.:
DSSTox Substance ID:DTXSID30150325
Nikkaji Number:J1.568.380E
Wikidata:Q27097348
Metabolomics Workbench ID:151267
Mol file:113215-69-3.mol

Synonyms:Ac-Leu-Phe-CF3;N-acetyl-L-leucyl-L-phenylalanyltrifluoromethane;N-acetyl-leucyl-phenylalanyl trifluoromethyl ketone

Suppliers and Price of N-Acetyl-leucyl-phenylalanyl trifluoromethyl ketone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of N-Acetyl-leucyl-phenylalanyl trifluoromethyl ketone

Chemical Property:

Vapor Pressure:4.95E-12mmHg at 25°C
Boiling Point:547.3°Cat760mmHg
Flash Point:284.8°C
PSA：92.34000
Density:1.186g/cm³
LogP:2.74700
XLogP3:3.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:372.16607709
Heavy Atom Count:26
Complexity:500

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)C(F)(F)F)NC(=O)C
Isomeric SMILES:CC(C)C[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)C(F)(F)F)NC(=O)C

Technology Process of N-Acetyl-leucyl-phenylalanyl trifluoromethyl ketone

There total 5 articles about N-Acetyl-leucyl-phenylalanyl trifluoromethyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 102196-01-0
(S)-2-Acetylamino-4-methyl-pentanoic acid (1-benzyl-3,3,3-trifluoro-2-hydroxy-propyl)-amide

: 189167-73-5,113215-69-3
(S)-2-Acetylamino-4-methyl-pentanoic acid (1-benzyl-3,3,3-trifluoro-2-oxo-propyl)-amide

Guidance literature:: With sodium hydroxide; potassium permanganate; In water; for 0.5h;
DOI:10.1016/S0040-4039(00)83960-X

Reference yield:

: 102195-92-6
3-nitro-4-phenyl-1,1,1-trifluorobutan-2-ol

: 189167-73-5,113215-69-3
(S)-2-Acetylamino-4-methyl-pentanoic acid (1-benzyl-3,3,3-trifluoro-2-oxo-propyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / 1) H₂, 2) conc. HCl / Raney Ni (W-2) / 2585.7 Torr

2: DCC / tetrahydrofuran / 4 h / Ambient temperature

3: 85 percent / potassium permanganate, 0.3 N NaOH / H₂O / 0.5 h

With hydrogenchloride; sodium hydroxide; potassium permanganate; hydrogen; dicyclohexyl-carbodiimide; Raney Ni (W-2); In tetrahydrofuran; water;
DOI:10.1016/S0040-4039(00)83960-X

Reference yield:

: 1188-21-2
N-Ac-Leu

: 189167-73-5,113215-69-3
(S)-2-Acetylamino-4-methyl-pentanoic acid (1-benzyl-3,3,3-trifluoro-2-oxo-propyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: DCC / tetrahydrofuran / 4 h / Ambient temperature

2: 85 percent / potassium permanganate, 0.3 N NaOH / H₂O / 0.5 h

With sodium hydroxide; potassium permanganate; dicyclohexyl-carbodiimide; In tetrahydrofuran; water;
DOI:10.1016/S0040-4039(00)83960-X