(S)-2-Acetylamino-4-methyl-pentanoic acid (1-benzyl-3,3,3-trifluoro-2-hydroxy-propyl)-amide

Base Information

• Chemical Name: (S)-2-Acetylamino-4-methyl-pentanoic acid (1-benzyl-3,3,3-trifluoro-2-hydroxy-propyl)-amide
• CAS No.: 102196-01-0
• Molecular Formula: C₁₈H₂₅F₃N₂O₃
• Molecular Weight: 374.403

Synonyms:(S)-2-Acetylamino-4-methyl-pentanoic acid (1-benzyl-3,3,3-trifluoro-2-hydroxy-propyl)-amide

Chemical Property of (S)-2-Acetylamino-4-methyl-pentanoic acid (1-benzyl-3,3,3-trifluoro-2-hydroxy-propyl)-amide

Chemical Property:

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Technology Process of (S)-2-Acetylamino-4-methyl-pentanoic acid (1-benzyl-3,3,3-trifluoro-2-hydroxy-propyl)-amide

There total 2 articles about (S)-2-Acetylamino-4-methyl-pentanoic acid (1-benzyl-3,3,3-trifluoro-2-hydroxy-propyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-nitro-4-phenyl-1,1,1-trifluorobutan-2-ol (102195-92-6) → (S)-2-Acetylamino-4-methyl-pentanoic acid (1-benzyl-3,3,3-trifluoro-2-hydroxy-propyl)-amide (102196-01-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / 1) H₂, 2) conc. HCl / Raney Ni (W-2) / 2585.7 Torr

2: DCC / tetrahydrofuran / 4 h / Ambient temperature

With hydrogenchloride; hydrogen; dicyclohexyl-carbodiimide; Raney Ni (W-2); In tetrahydrofuran;

DOI:10.1016/S0040-4039(00)83960-X

Reference yield:

N-Ac-Leu (1188-21-2) + 2-hydroxy-3-amino-4-phenyl-1,1,1-trifluorobutane hydrochloride (123206-13-3) → (S)-2-Acetylamino-4-methyl-pentanoic acid (1-benzyl-3,3,3-trifluoro-2-hydroxy-propyl)-amide (102196-01-0)

Guidance literature:

With dicyclohexyl-carbodiimide; In tetrahydrofuran; for 4h; Ambient temperature;

DOI:10.1016/S0040-4039(00)83960-X

Reference yield: 85.0%

(S)-2-Acetylamino-4-methyl-pentanoic acid (1-benzyl-3,3,3-trifluoro-2-hydroxy-propyl)-amide (102196-01-0) → (S)-2-Acetylamino-4-methyl-pentanoic acid (1-benzyl-3,3,3-trifluoro-2-oxo-propyl)-amide (189167-73-5,113215-69-3)

Guidance literature:

With sodium hydroxide; potassium permanganate; In water; for 0.5h;

DOI:10.1016/S0040-4039(00)83960-X

upstream raw materials:

N-Ac-Leu

2-hydroxy-3-amino-4-phenyl-1,1,1-trifluorobutane hydrochloride

3-nitro-4-phenyl-1,1,1-trifluorobutan-2-ol

Downstream raw materials:

(S)-2-Acetylamino-4-methyl-pentanoic acid (1-benzyl-3,3,3-trifluoro-2-oxo-propyl)-amide

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