(E)-3-(2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acrylic acid

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Chemical Name:(E)-3-(2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acrylic acid
CAS No.:1421850-07-8
Molecular Formula:C₂₀H₂₁N₃O₃S
Molecular Weight:383.471
Hs Code.:

Synonyms:(E)-3-(2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acrylic acid

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Chemical Property of (E)-3-(2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acrylic acid

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Technology Process of (E)-3-(2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acrylic acid

There total 9 articles about (E)-3-(2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1421850-06-7
ethyl (E)-3-(2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acrylate

: 1421850-07-8
(E)-3-(2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acrylic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; methanol; at 0 - 60 ℃; for 3h;

Reference yield:

: 2881-83-6
ethyl 4-methoxybenzoylacetate

: 1421850-07-8
(E)-3-(2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acrylic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: toluene / 14 h / 90 °C

1.2: 20 h / 80 °C

2.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 1 h / 20 °C

3.1: thionyl chloride / toluene / 2.5 h / 100 °C

3.2: 14 h / 20 °C

4.1: Lawessons reagent / tetrahydrofuran / 0.33 h / 60 °C

5.1: ethanol / 14 h / 90 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

7.1: sulfur trioxide pyridine complex / dimethyl sulfoxide / 14 h / 20 °C

8.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 - 20 °C

8.2: 5 h / 0 - 20 °C

9.1: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h / 0 - 60 °C

With Lawessons reagent; lithium aluminium tetrahydride; thionyl chloride; water; sulfur trioxide pyridine complex; sodium hydride; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; toluene; mineral oil;

Reference yield:

: 1421848-81-8
1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazole-4-carboxylic acid

: 1421850-07-8
(E)-3-(2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acrylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride / toluene / 2.5 h / 100 °C

1.2: 14 h / 20 °C

2.1: Lawessons reagent / tetrahydrofuran / 0.33 h / 60 °C

3.1: ethanol / 14 h / 90 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

5.1: sulfur trioxide pyridine complex / dimethyl sulfoxide / 14 h / 20 °C

6.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 - 20 °C

6.2: 5 h / 0 - 20 °C

7.1: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h / 0 - 60 °C

With Lawessons reagent; lithium aluminium tetrahydride; thionyl chloride; water; sulfur trioxide pyridine complex; sodium hydride; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; toluene; mineral oil;